CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Summary: The development and operation of chloroplasts depends on the correct targeting, translocation, assembly and degradation of thousands of different chloroplast proteins. An overview of these diverse proteostatic processes is presented.
Summary: We discuss shear stress in response to fluid dynamics and invite the reader to study shear stress in biological systems, in which shear stress emerges from cell and tissue interactions.
Live-imaging studies reveal how microclots and the associated inflammatory response enhance cancer cell extravasation
Highlighted Article: Live imaging in zebrafish larvae reveals that fibrin and platelets in the pre-metastatic niche can recruit pro-metastatic innate immune cells and drive cancer metastasis.
Paxillin regulates liver fibrosis via actin polymerization and ERK activation in hepatic stellate cells
Highlighted Article: Paxillin is shown to be a key molecule important in the function of fibrosis effector cells, which emphasizes a novel role for it in liver fibrosis and cirrhosis, a leading cause of morbidity and mortality worldwide.
Surf4 collaborates with derlin-2 and derlin-1 to mediate cyclooxygenase-2 translocation to the cytosol for degradation
Highlighted Article: An endoplasmic reticulum-associated degradation pathway mediated by derlin-2, derlin-1, Surf4 and caveolin-1 facilitates cyclooxygenase-2 translocation and degradation.
Shock drives a STAT3 and JunB-mediated coordinated transcriptional and DNA methylation response in the endothelium
Summary: LPS triggers a SOCS3-dependent epigenetic and transcriptional coordinated response in the kidney endothelium. Experiments in cultured endothelial cells show that this response depends at least in part on IL-6-induced STAT3 and JunB activity.
The E3 ubiquitin ligase CHIP drives monoubiquitylation-mediated nuclear import of the tumor suppressor PTEN
Summary: Following CHIP-mediated monoubiquitylation, PTEN undergoes nuclear import, which is aided by KPNA1 and enhanced by oxidative stress. PTEN monoubiquitylation also increases its interaction with nuclear CHIP.
Summary: ILT4 is identified as an unfavorable prognostic biomarker as well as a novel driver for triple-negative breast cancer (TNBC) progression, suggesting that targeting ILT4 could be a strategy to combat TNBC.
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Schwann cells are axo-protective after injury irrespective of myelination status in mouse Schwann cell–neuron cocultures
Highlighted Article: A novel method for compartmentalised mouse myelinating Schwann cell–DRG neuron cocultures, showing that Schwann cell myelination status does not influence their axon protective effect after injury.