Issues
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Cover image
Cover Image
Cover: A super-resolution structured illumination microscopy image of the ciliate Tetrahymena thermophila with immunofluorescence labelling of polyglycylated tubulin (green) and centrin (red). DNA is stained using DAPI (blue). See article by C. Lee et al. (jcs261256).
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Special Issue: Cell and Tissue Polarity
EDITORIAL
CELL SCIENTISTS TO WATCH
PERSPECTIVE
Perspectives on polarity – exploring biological asymmetry across scales
Summary: Researchers working on cell and tissue polarity across scales share their thoughts on unique, emerging or open questions relating to their field.
CELL SCIENCE AT A GLANCE
The Drosophila neuroblast polarity cycle at a glance
Summary: A review highlighting the intersecting dynamics of polarity proteins, fate determinants, cortical actin and plasma membrane morphology throughout the cell cycle of Drosophila neural stem cells.
Polarity establishment in the plant zygote at a glance
Summary: This Cell Science at a Glance article provides basic knowledge and the latest findings on the mechanism of zygote polarization in Arabidopsis thaliana as obtained through live-imaging analysis of the zygote.
REVIEWS
Inverted apicobasal polarity in health and disease
Summary: Review of the molecular alterations associated with inverted apicobasal polarity and their consequences in health and disease.
The contribution of asymmetric cell division to phenotypic heterogeneity in cancer
Summary: In this Review, we delve into the occurrence of asymmetric cell division in cancer cells, assessing how this phenomenon contributes to cancer heterogeneity.
SHORT REPORTS
TIAM-1 regulates polarized protrusions during dorsal intercalation in the Caenorhabditis elegans embryo through both its GEF and N-terminal domains
Summary: The Rac-GEF TIAM-1 promotes contralateral migration via its GEF domain, whereas its N-terminal domains suppress ectopic filiform protrusions around the periphery during mediolateral intercalation of dorsal epidermal cells in the Caenorhabditis elegans embryo.
Integrin-based adhesions promote cell–cell junction and cytoskeletal remodelling to drive embryonic wound healing
Summary: There is an interplay between integrin-based adhesion and adherens junctions that regulates actin polarization and dynamics during the collective cell movements that drive wound healing in the Drosophila embryonic epidermis.
Cdc42 couples septin recruitment to the axial landmark assembly via Axl2 in budding yeast
Summary: Cdc42 plays a key role in establishing a single axis of cell polarization. In budding yeast, Cdc42 couples septin recruitment to the axial landmark via Axl2, a landmark protein.
RESEARCH ARTICLES
MUC13 negatively regulates tight junction proteins and intestinal epithelial barrier integrity via protein kinase C
Summary: The transmembrane mucin MUC13 reduces intestinal barrier function by negative regulation of epithelial tight junction strength via protein kinase C.
Steroid hormone signaling synchronizes cell migration machinery, adhesion and polarity to direct collective movement
Summary: Steroid hormone signaling coordinates adhesion, polarity and membrane contractility in collectively migrating border cells. This regulates functional protrusion dynamics, enabling timely migration.
PALS1 is a key regulator of the lateral distribution of tight junction proteins in renal epithelial cells
Summary: PALS1 has a crucial role in coupling of the elongation of tight junction protein condensates with F-actin polymerization at the junctional area of epithelial cells.
Polo-like kinase 1 regulates immune synapse assembly and cytotoxic T cell function by driving microtubule dynamics
Summary: The mitotic kinase Polo-like kinase 1 promotes centrosome polarization to the immune synapse in cytotoxic T cells by coupling TCR signaling to microtubule dynamics.
Regulation of the apico-basolateral trafficking polarity of the homologous copper-ATPases ATP7A and ATP7B
Summary: The adaptor protein-1 (AP-1) isoforms AP-1A and AP-1B govern the apico-basolateral trafficking polarities of the homologous copper-ATPases ATP7A and ATP7B at the trans-Golgi network.
Interplay between the plasma membrane and cell–cell adhesion maintains epithelial identity for correct polarised cell divisions
Summary: In this study, we identify a plasma membrane-mediated mechanism that maintains epithelial cell identity to ensure correct execution of polarised cell divisions, genome maintenance and safeguard tissue integrity.
Crb3 is required to organize the apical domain of multiciliated cells
Summary: Crb3 could cooperate with Ezrin and Rab11a to allow basal body migration and construction of the apical actin meshwork of multicilated cells in Xenopus embryos.
The epithelial polarity axis controls the resting membrane potential and Cl− co-transport in breast glandular structures
Summary: There is a central role for epithelial polarity in controlling cell homeostasis via an impact on the membrane potential.
Global and local functions of the Fused kinase ortholog CdaH in intracellular patterning in Tetrahymena
Summary: CdaH, a conserved Fused kinase, acts at multiple stages and scales to generate a pattern of cortical organelles during cell division in the ciliate Tetrahymena thermophila.
Fat2 polarizes Lar and Sema5c to coordinate the motility of collectively migrating epithelial cells
Summary: In the migrating follicular epithelium of Drosophila, trailing edge-enriched Fat2 concentrates Lar and Sema5c in trans at leading edges; they then act in parallel to promote collective migration.
HOPS-dependent lysosomal fusion controls Rab19 availability for ciliogenesis in polarized epithelial cells
Summary: Loss of HOPS-mediated lysosomal fusion indirectly blocks apical actin clearing and ciliogenesis in polarized epithelia by trapping Rab19 on late endosomes and depleting Rab19 from the basal body.
Paracingulin recruits CAMSAP3 to tight junctions and regulates microtubule and polarized epithelial cell organization
Summary: The junctional protein CGNL1 controls the localization of CAMSAP3 at apical epithelial junctions, as well as the organization of microtubules and the polarized architecture of epithelial cells in vitro and in vivo.
TOOLS AND RESOURCES
Trophoblast organoids with physiological polarity model placental structure and function
Summary: A method to culture trophoblast organoids (TOs) derived from human placental tissue that recapitulates the cellular orientation of chorionic villi in vivo, thus allowing for studies of placental biology under physiological conditions.
FIRST PERSON
Imaging Cell Architecture and Dynamics
We are still welcoming submissions for our upcoming Special Issue: Imaging Cell Architecture and Dynamics. This issue will be coordinated by two Guest Editors: Lucy Collinson (The Francis Crick Institute, UK) and Guillaume Jacquemet (University of Turku, Finland). Extended submission deadline: 29 March 2024.
Journal of Cell Science - more than just a journal
People who know JCS well will know that we're more than just a journal and that our community – the cell biology community – really is at the heart of everything we do. Read the full Editorial by Editor-in-Chief Michael Way and Executive Editor Seema Grewal.
2024 Journal Meeting 'Diversity and Evolution in Cell Biology'
Registration is open for our 2024 Journal Meeting Diversity and Evolution in Cell Biology, which aims to bring together evolutionary biologists and cell biologists investigating diverse aspects of cellular physiology. Submit your abstract by 5 April. Final registration deadline: 3 May 2024.
Workshop: Roles of Lipids in Nuclear Homeostasis and Genome Stability
Early-career researchers interested in the roles of nuclear lipids, apply now for one of the ten funded places at this Workshop, which will take place 14-17 October 2024. Application deadline: 19 April.
Reasons to submit to Journal of Cell Science
There are many benefits to publishing in Journal of Cell Science - read more about why you should choose JCS or visit our submission page now.