Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments by Henrichs et al.
Henrichset al. employ in vitro stepping assays with the kinesin-1 KIF5B and its adaptor TRAK1 to understand how they form a complex that transports mitochondria on crowded microtubules.
Selected by Vaishnavi Ananthanarayanan. Read the guest preLight here
Architecture of the AP2:clathrin coat on the membranes of clathrin-coated vesicles by Kovtun et al.
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The Structures of Natively Assembled Clathrin Coated Vesicles by Paraan et al.
Coat coterie: Two preprints from Kovtun et al. and Paraan et al. show us high resolution glimpses of clathrin and friends, assembled on membranes.
Selected by Stephen Royle. Read the guest preLight here
Dissecting the nanoscale lipid profile of caveolae by Zhou et al.
Caveolae organize a network of specific lipid species to define a unique plasma membrane lipid environment.
Selected by Gerry Hammond. Read the guest preLight here
Loss of epithelial polarity redirects Notch signaling and triggers a Xrp1 response during neoplastic growth in Drosophila by Logeay et al.
Invasive Procedure: new insights into how changes in epithelial structure can turn Notch nasty.
Selected by Sally Lowell. Read the guest preLight here
Bacterial FtsZ induces mitochondrial fission in human cells by Spier et al.
Does the mitochondrial inner membrane possess a unique fission machinery? Spier et al. show that FtsZ, which is a protein responsible for bacterial division, induces mitochondrial inner-membrane fission when expressed in human mitochondria.
Selected by Leeba Ann Chacko. Read the preLight here
The nucleus acts as a ruler tailoring cell responses to spatial constraints by Lomakin et al.
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The nucleus measures shape deformation for cellular proprioception and regulates adaptive morphodynamics by Venturini et al.
Can cells measure up? The nucleus acts as a cellular ruler during migration through 3D environments.
Selected by Nicola Stevenson. Read the preLight here
Skd3 (human CLPB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations by Cupo & Shorter
Long-lost mitochondrial disaggregase has been found.
Selected by Tessa Sinnige. Read the preLight here
The WD and linker domains of ATG16L1 required for non-canonical autophagy limit lethal influenza A virus infection at epithelial surfaces by Wang et al.
Loss of non-canonical autophagy in mice increases sensitivity to influenza A virus infection by disrupting defences at the lung epithelial barrier, but not in phagocytic leukocytes.
Selected by Kirsty Hooper. Read the preLight here
Closed mitosis requires local disassembly of the nuclear envelope by Dey et al.
What is the mechanism behind closed mitosis in S.pombe? Dey et al. show how a protein named ‘Les1’ ensures the local disassembly of the nuclear envelope on the bridge that connects the two daughter nuclei, thus preventing leakage of nuclear material.
Selected by Leeba Ann Chacko. Read the preLight here
Mechanical control of morphogenesis robustness by Martin et al.
Feel the force - anisotropic tissue tension, away from cell shape changes, is essential for morphogenesis robustness in Drosophila leg formation.
Selected by Helen Zenner. Read the preLight here
Obesity-driven changes in ECM composition promote local invasion and metastasis of breast tumors by Wishart et al.
Obesity and breast cancer – Collagen VI in the spotlight.
Selected by Vassilis Papalazarou and Anh Hoang Le. Read the preLight here
DRP1-mediated regulation of mitochondrial dynamics determines the apoptotic response upon embryonic differentiation by Pernaute et al.
Higher sensitivity to apoptosis driven by mitochondrial dynamics: Lowering of the apoptotic threshold in the post-implantation embryo is regulated by changes in mitochondrial shape and connectivity.
Selected by Katarzyna Kuzmicz-Kowalska. Read the preLight here
Antigenic variation by switching inter-chromosomal interactions with an RNA splicing locus in trypanosomes by Faria et al.
A look into the host-pathogen arms race: distinct DNA-DNA interactions ensuring monogenic VSG expression in T. brucei.
Selected by Mariana De Niz. Read the preLight here
On-demand spatiotemporal programming of collective cell migration via bioelectric stimulation by Zajdel et al.
An electricity-based pied piper of Hamelin: moving cells on demand.
Selected by Mariana De Niz. Read the preLight here
Molecular and cellular dissection of the OSBP cycle through a fluorescent inhibitor by Péresse et al.
An intrinsically fluorescent, natural product specifically inhibits the lipid transport protein OSBP.
Selected by Berrak Ugur. Read the preLight here
Membrane tension mediated mechanotransduction drives fate choice in embryonic stem cells by De Belly et al.
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Cell surface mechanics gate stem cell differentiation by Bergert et al.
Fate choice at the cell's edge: Two complimentary preprints show that plasma membrane tension regulates stem cell fate.
Selected by Joseph Jose Thottacherry. Read the preLight here
vLUME: 3D Virtual Reality for Single-molecule Localization Microscopy by Spark et al.
vLUME: One step into the fascinating super-resolved world.
Selected by Mariana De Niz. Read the preLight here
Super-Beacons: open-source probes with spontaneous tuneable blinking compatible with live-cell super-resolution microscopy by Pereira et al.
Super-Beacons: making super-resolution live-cell friendly.
Selected by Mariana De Niz. Read the preLight here
