Defining how Pak1 regulates cell polarity and cell division in fission yeast by Magliozzi et al.
How does a protein kinase regulate events during cell division? This recent preprint sheds light on how ‘Pak1’ directly influences cell division all the way from initiation to separation in S. pombe.
Direct Arp2/3-vinculin binding is essential for cell spreading, but only on compliant substrates and in 3D by Isogai et al.
2D or 3D: Cells mould themselves.
The Wnt pathway scaffold protein Axin promotes signaling specificity by suppressing competing kinase reactions by Gavagan et al.
Axin, a Wnt pathway scaffold protein, promotes GSK3β affinity for β-catenin and suppresses GSK3β affinity for competing substrates.
Delineating the rules for structural adaptation of membrane-associated proteins to evolutionary changes in membrane lipidome by Makarova et al.
Greasing the wheels of change: probing the co-evolution of lipid chemistry and membrane-associated proteins using related fission yeasts.
A conserved ATG2-GABARAP interaction is critical for phagophore closure by Bozic et al.
ATG2- autophagosome closing cue. Great insight into the function of ATG2A/B proteins in cells.
CLIJ: GPU-accelerated image processing for everyone by Haase et al.
CLIJ: a tool that overcomes an important bottleneck in the microscopy workflow by bringing accelerated processing speed to everyone, regardless of coding skills.
Quantitative intravital imaging of Plasmodium falciparum sporozoites: A novel platform to test malaria intervention strategies by Hopp et al.
One for all: IVM shows comparable dynamics of human and rodent Plasmodium sporozoites in murine skin, offering a promising tool to investigate anti-malarial intervention targeting sporozoites at the point of inoculation.
The histone chaperone FACT induces Cas9 multi-turnover behavior and modifies genome manipulation in human cells by Wang et al.
Cutting to the FACT of the matter – the FACT histone chaperone complex can modify Cas9 behaviour during gene editing, potentially influencing the outcome of different CRISPR approaches.