Defining how Pak1 regulates cell polarity and cell division in fission yeastby Magliozzi et al.

How does a protein kinase regulate events during cell division? This recent preprint sheds light on how ‘Pak1’ directly influences cell division all the way from initiation to separation in S. pombe.

Selected by Leeba Ann Chacko. Read the preLight here

Direct Arp2/3-vinculin binding is essential for cell spreading, but only on compliant substrates and in 3Dby Isogai et al.

2D or 3D: Cells mould themselves.

Selected by Ankita Jha. Read the preLight here

The Wnt pathway scaffold protein Axin promotes signaling specificity by suppressing competing kinase reactionsby Gavagan et al.

Axin, a Wnt pathway scaffold protein, promotes GSK3β affinity for β-catenin and suppresses GSK3β affinity for competing substrates.

Selected by Yasmin Lau. Read the preLight here

Delineating the rules for structural adaptation of membrane-associated proteins to evolutionary changes in membrane lipidomeby Makarova et al.

Greasing the wheels of change: probing the co-evolution of lipid chemistry and membrane-associated proteins using related fission yeasts.

Selected by Gautam Dey. Read the preLight here

A conserved ATG2-GABARAP interaction is critical for phagophore closureby Bozic et al.

ATG2- autophagosome closing cue. Great insight into the function of ATG2A/B proteins in cells.

Selected by Mila Basic. Read the preLight here

CLIJ: GPU-accelerated image processing for everyoneby Haase et al.

CLIJ: a tool that overcomes an important bottleneck in the microscopy workflow by bringing accelerated processing speed to everyone, regardless of coding skills.

Selected by Mariana De Niz. Read the preLight here

Quantitative intravital imaging of Plasmodium falciparum sporozoites: A novel platform to test malaria intervention strategiesby Hopp et al.

One for all: IVM shows comparable dynamics of human and rodent Plasmodium sporozoites in murine skin, offering a promising tool to investigate anti-malarial intervention targeting sporozoites at the point of inoculation.

Selected by Mariana De Niz. Read the preLight here

The histone chaperone FACT induces Cas9 multi-turnover behavior and modifies genome manipulation in human cellsby Wang et al.

Cutting to the FACT of the matter – the FACT histone chaperone complex can modify Cas9 behaviour during gene editing, potentially influencing the outcome of different CRISPR approaches.

Selected by Nicola Stevenson. Read the preLight here