Mathematical modelling is increasingly being used to generate testable models of complex biological processes and predict how cells behave under particular conditions. On p. 1381, Alex Mogilner and co-workers provide a good example of this, introducing a mathematical model that describes microtubule self-organization in fish melanocyte fragments. In these fragments, dynein motors associated with pigment granules are able to direct formation of radial microtubule arrays in the absence of centrosomes. Mogilner and co-workers base their model on the observed sequence of events that follow stimulation of these motors: granule clustering, nucleation of microtubules, and further clustering to produce a single microtubule array. In addition, they incorporate numerous experimentally determined parameters, such as the microtubule treadmilling rate, the size of the melanocyte fragments and the granule dissociation rate. In computational simulations, the model accurately reproduces the pathways of granule aggregation and microtubule self-organization observed in vivo. The authors anticipate that it will not only yield further insights into the intrinsic properties of self-organizing microtubule/motor systems but also shed light on centrosome-governed microtubule arrays.
Modelling microtubules
Modelling microtubules. J Cell Sci 15 March 2004; 117 (8): e805. doi:
Download citation file:
Advertisement
Cited by
Introducing our new Editors
We welcome three new Editors to Journal of Cell Science - Robert Parton, Richa Rikhy and Simon Cook. You can read more about them in the Editorial from our Editor-in-Chief Michael Way.
2024 Journal Meeting 'Diversity and Evolution in Cell Biology'
Registration is open for our 2024 Journal Meeting Diversity and Evolution in Cell Biology, which aims to bring together evolutionary biologists and cell biologists investigating diverse aspects of cellular physiology. Final registration deadline: 3 May 2024.
Workshop: Physics of the Early Embryonic Cell Divisions
Early-career researchers interested in the roles of nuclear lipids, apply now for one of the ten funded places at this Workshop, which will take place 11-14 November 2024. Application deadline: 17 May.
Reasons to submit to Journal of Cell Science
There are many benefits to publishing in Journal of Cell Science - read more about why you should choose JCS or visit our submission page now.
Propose a new Workshop for 2026
We are now accepting proposals for our 2026 Workshops programme. We aim to be responsive to the community and open to novel initiatives, so if you have a new idea for a biological workshop that you feel would work well, please apply. Applications deadline: 19 July 2024.