Signalling through receptors for cytokines and numerous growth factors activates members of the Janus kinase (also comically known as `just another kinase' or more simply JAK) family. These in turn switch on signal transducers and activators of transcription (STATs), which regulate transcription of various target genes. There are at least four JAKs and seven STATs in mammals - not to mention an array of endogenous inhibitors termed suppressors of cytokine signalling (SOCS). In Cell Science at a Glance (see p. 1281 + poster), Douglas Harrison and co-workers survey the JAK/STAT signalling pathway, detailing the various points at which crosstalk with other signalling mechanisms occurs, as well as the consequences of mutations in particular JAK and STAT genes.
STATs for JAKs
STATs for JAKs. J Cell Sci 15 March 2004; 117 (8): e803. doi:
Download citation file:
Advertisement
Cited by
Introducing our new Editors
We welcome three new Editors to Journal of Cell Science - Robert Parton, Richa Rikhy and Simon Cook. You can read more about them in the Editorial from our Editor-in-Chief Michael Way.
2024 Journal Meeting 'Diversity and Evolution in Cell Biology'
Registration is open for our 2024 Journal Meeting Diversity and Evolution in Cell Biology, which aims to bring together evolutionary biologists and cell biologists investigating diverse aspects of cellular physiology. Final registration deadline: 3 May 2024.
Workshop: Physics of the Early Embryonic Cell Divisions
Early-career researchers interested in the roles of nuclear lipids, apply now for one of the ten funded places at this Workshop, which will take place 11-14 November 2024. Application deadline: 17 May.
Reasons to submit to Journal of Cell Science
There are many benefits to publishing in Journal of Cell Science - read more about why you should choose JCS or visit our submission page now.
Propose a new Workshop for 2026
We are now accepting proposals for our 2026 Workshops programme. We aim to be responsive to the community and open to novel initiatives, so if you have a new idea for a biological workshop that you feel would work well, please apply. Applications deadline: 19 July 2024.