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Keywords: Xenograft
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Journal Articles
Dis Model Mech (2020) 13 (10): dmm046904.
Published: 28 October 2020
... models, and an array of transgenic and xenograft in vivo models, with particular attention to newly developed systems and how they are being used to deepen our understanding of FSHD pathology and to test the efficacy of drug candidates. Fig. 3. Xenograft models of FSHD. Existing muscle tissue...
Journal Articles
In collection:
Cancer
Dis Model Mech (2019) 12 (9): dmm040386.
Published: 6 September 2019
... preclinical modelling of glioblastoma multiforme to understand its biology and develop therapies, with a focus on mammalian model systems. Central nervous system In vitro CRISPR/Cas9 Mouse Human Xenograft GBM Cancer Brain tumour “All models are wrong, but some are useful.” – George E...
Journal Articles
Dis Model Mech (2018) 11 (12): dmm035998.
Published: 29 November 2018
... strategies have had limited clinical success. Tumour-associated myeloid cells are believed to play a role in the resistance of cancer towards anti-angiogenesis therapy, but the mechanisms by which they do this are unclear. An embryonic zebrafish xenograft model has been developed to investigate...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (5): dmm032250.
Published: 29 May 2018
... to spontaneously metastatic to lung, liver, spleen and lymph node. Single nucleotide polymorphism (SNP) array analyses and genome-wide mRNA expression profiles of tumour cells isolated from orthotopic mammary xenografts were compared between the four lines to define both cell autonomous pathways and genes...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (5): dmm032292.
Published: 18 May 2018
... of the mutations and genes that mediate resistance is incomplete. In this study, by modeling chemoresistance in patient-derived xenografts (PDXs), we show that adaptation to therapy is genetically complex and identify that loss of transcription factor 4 (TCF4; also known as ITF2) is associated with this process...
Includes: Supplementary data
Journal Articles
In collection:
Cancer
Dis Model Mech (2016) 9 (12): 1435–1444.
Published: 1 December 2016
...) for heterotypic in vivo modeling that recapitulates the heterogeneous biology and behavior of this disease. Both cell lines demonstrated stability of the transcriptome when grown as orthotopic xenografts in athymic nude mice. Consistent with the behavior of the original tumors, OS-2 xenografts grew more rapidly...
Includes: Supplementary data
Journal Articles
In collection:
Cancer
Dis Model Mech (2016) 9 (2): 141–153.
Published: 1 February 2016
... clinical experimentation, still no effective therapeutic approaches have been established to block CXCR4 in TNBC. To unravel the role of the CXCR4-CXCL12 axis in the formation of TNBC early metastases, we used the zebrafish xenograft model. Importantly, we demonstrate that cross-communication between...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (10): 1247–1254.
Published: 1 October 2015
... or high expression of Myc oncoproteins. In a previous in vitro study, we found that the glycolytic inhibitor 2-deoxyglucose (2DG) could suppress the growth of neuroblastoma cells, particularly in those with MYCN amplification. In this study, we established a mouse model of neuroblastoma xenografts with SK...
Includes: Supplementary data