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Keywords: Vesicular uptake
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Journal Articles
Regev Landau, Reut Halperin, Patti Sullivan, Zion Zibly, Avshalom Leibowitz, David S. Goldstein, Yehonatan Sharabi
Journal:
Disease Models & Mechanisms
Dis Model Mech (2022) 15 (1): dmm049082.
Published: 24 January 2022
..., DOPAL is the missing link. Inhibition of the mitochondrial complex 1 by rotenone decreases availability of NAD+, a required co-factor for detoxifying DOPAL. The energy crisis in dopaminergic neurons also impedes ATP-dependent vesicular uptake of catecholamines, meaning that the fate of cytoplasmic...
