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Keywords: Tumour heterogeneity
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Journal Articles
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Dis Model Mech (2022) 15 (1): dmm049233.
Published: 11 January 2022
... – evasion of apoptosis, tissue invasion and metastasis, altered cellular metabolism, genome instability and drug resistance. Emerging evidence indicates that the dysregulation of alternative splicing also promotes a permissive environment for increased tumour heterogeneity and cellular plasticity...
Journal Articles
Dis Model Mech (2018) 11 (8): dmm033464.
Published: 28 June 2018
... Cancer stem cells Therapy resistance Tumour heterogeneity Cancer is widely known to be a heterogeneous disease, in which malignant cells communicate with various other cell types, such as endothelial, haematopoietic and stromal cells (see Glossary, Box 1 ). This complex system within a tumour...