... to be addressed to improve the application of these tools to the heart and their translation to the clinic. This article is part of a collection ‘Moving Heart Failure to Heart Success: Mechanisms, Regeneration & Therapy’, which was launched in a dedicated Special Issue guest edited by Jeroen Bakkers...

... of cell senescence in the lumbar spinal cord, with selective sensitivity to senolytic treatments. Amyotrophic lateral sclerosis Navitoclax Senolytic Neuroinflammation Therapy Cell cycle Cryptic exon Instituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 PI 17-00134...

...Suzie Buono; Arnaud Monseur; Alexia Menuet; Anne Robé; Catherine Koch; Jocelyn Laporte; Leen Thielemans; Marion Depla; Belinda S. Cowling ABSTRACT Generating reliable preclinical data in animal models of disease is essential in therapy development. Here, we performed statistical analysis and joint...

...Belinda S. Cowling; Leen Thielemans ABSTRACT Although around half of US Food and Drug Administration (FDA)-approved drugs originate from discoveries made in academic research laboratories, the US National Institutes of Health (NIH) estimates that nearly 90% of therapies developed in preclinical...