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Keywords: Rapamycin
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Journal Articles
Dis Model Mech (2021) 14 (10): dmm049018.
Published: 26 October 2021
... mice as an experimental model to investigate the potential role of rapamycin, a mammalian target of rapamycin inhibitor, as an adjunctive therapy candidate during the treatment of Mycobacterium tuberculosis infection with moxifloxacin. We report that administration of rapamycin with or without...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (2): dmm033803.
Published: 7 February 2019
... in cellular reactive oxygen species, which, in turn, triggers proteasomal degradation. ALS Autophagy UPS Aggregate Rapamycin MG132 Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disease characterized by loss of motor neurons, resulting in muscular atrophy...
Includes: Supplementary data
Journal Articles
In collection:
Metabolic Disorders
Dis Model Mech (2016) 9 (1): 51–61.
Published: 1 January 2016
... of Langerhans and plays a role in the modulation of insulin secretion and expansion of the β-cell mass. The downstream signalling pathways mediating these effects are poorly understood. Mammalian target of rapamycin complex 1 (mTORC1) signalling is a key intracellular pathway involved in energy homeostasis...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (9): 1059–1069.
Published: 1 September 2015
... of protein synthesis and muscle mass. Interestingly, immobilization also induced an increase in mTOR signaling, eIF4F complex formation and cap-dependent translation. Blocking mTOR signaling during immobilization with rapamycin not only impaired the increase in eIF4F complex formation, but also augmented...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2014) 7 (7): 907–913.
Published: 1 July 2014
... expression, ultimately leading to larval death. The zebrafish tumors share characteristics of human chordoma as demonstrated by immunohistochemistry and electron microscopy. The mTORC1 inhibitor rapamycin, which has some demonstrated activity in a chordoma cell line, delays the onset of tumor formation...
Includes: Supplementary data