... introduced in recent years. In this At a Glance article, we discuss the available methods to generate such models, grouped according to the following classification: cardiac organoids, cardiac microtissues and engineered cardiac tissues. For these models, we provide a systematic overview...

... with fewer than 20 cells per circumference were excluded from analysis, and the average number of cells scored per enteroids was 118 (range 46-239). The proportion of cells nuclear stained for p65 was quantified for each organoid using manual cell counting by a scorer experienced in quantitative histological...

... and function with organoids derived from human pluripotent stem cells. These have successfully recapitulated not only kidney differentiation, but also the specific phenotypical traits related to kidney function. The combination of this methodology with CRISPR/Cas9 genome editing has already helped researchers...

.... We also highlight the emerging disease models derived from human clinical samples, including patient-derived xenograft models and organoids, which may provide biological and therapeutic insights into GEP-NENs. We thank the laboratory members, especially Dr Satoko Kaneko, for their support. We...