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Keywords: Neural crest
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Journal Articles
In collection:
The RAS Pathway
Dis Model Mech (2022) 15 (2): dmm047357.
Published: 04 May 2021
..., including pediatric dysphagia. Using the LgDel 22q11DS mouse model, we investigated whether sensory neuron differentiation in the trigeminal ganglion (CNgV), which is essential for normal orofacial function, is disrupted. We did not detect changes in cranial placode cell translocation or neural crest...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (3): dmm043489.
Published: 03 March 2020
... and highly variable disruptions in the size of the domains of neural border zone, neural crest and pre-placodal ectoderm genes. Each mutant also had differential effects on genes that pattern the otic vesicle. Assessment of the tadpole inner ear demonstrated that while the auditory and vestibular structures...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (9): 1101–1108.
Published: 01 September 2017
... remodeling or septation leads to abnormalities collectively known as conotruncal defects, which are associated with significant mortality and morbidity. Multiple populations of cells must interact to coordinate outflow tract remodeling, and the cardiac neural crest has emerged as particularly important...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2016) 9 (6): 607–620.
Published: 01 June 2016
... stem and progenitor cell population, which is designated the neural crest (NC). Musculocontractural Ehlers–Danlos syndrome (MCEDS) is a heritable connective tissue disorder with distinct craniofacial features; this syndrome comprises multiple congenital malformations that are caused by dysfunction...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2016) 9 (4): 413–425.
Published: 01 April 2016
... receptor protein 2 (LRP2) is important for development of the embryonic neural crest and brain in both mice and humans. Although a role in cardiovascular development can be expected, the hearts of Lrp2 knockout (KO) mice have not yet been investigated. We studied the cardiovascular development of Lrp2 KO...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2016) 9 (4): 389–400.
Published: 01 April 2016
... reporter in zebrafish for rapid drug screening, called Tg(snai1b:GFP) , which labels epithelial cells undergoing EMT to produce sox10 -positive neural crest (NC) cells. Time-lapse and lineage analysis of Tg(snai1b:GFP) embryos reveal that cranial NC cells delaminate from two regions: an early population...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (8): 855–866.
Published: 01 August 2015
.... In light of these findings, we utilized the talpid 2 model to examine the cellular basis for the oral-facial phenotypes present in OFD. Specifically, we examined the development and differentiation of cranial neural crest cells (CNCCs) when C2CD3-dependent ciliogenesis was impaired. Our studies suggest...
Includes: Supplementary data