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In collection:Rat as a Disease Model
Journal: Disease Models & Mechanisms
Dis Model Mech (2021) 14 (3): dmm048041.
Published: 24 March 2021
... in survival rate. Architecture and function of the kidneys in UOX -KO rats were impaired. Injury to the kidney resulted in increased interstitial fibrosis, macrophage infiltration, increased expression of NLRP3 and IL-1β, and activation of multiple cell-signaling pathways associated with autophagy...