.... demo data. (B) Main tabs of the app. (C) Drop-down menu to select a specific model to visualize the fitted lines. (D) Plot of the original data and fitted lines for the higher-level random effect variable in the maximal model (Donor Intercept/Slope+Mouse Intercept/Slope). Fig. 2. Study...

... of the contributions of bacterial factors to colonization of and shedding from the nasopharynx, as occurs during the catarrhal stage of pertussis, and interventions that might better control the ongoing circulation of pertussis. Fig. 2. B. pertussis -induced histopathology of mouse nasal cavity. (A,B...

... regeneration and resolution of advanced liver fibrosis in mice. Chronic liver disease Liver regeneration Fibrosis resolution Inflammation Macrophages Thioacetamide Mouse National Health and Medical Research Council http://dx.doi.org/10.13039/501100000925 APP1162171 Mater...

.... All the mutations were predicted to affect protein synthesis. We extended our analysis to knock-in mouse models of APOE alleles and found the same effect for the late onset Alzheimer's disease risk allele ε4. Our results support a common molecular basis for the initiation of the pathological processes...

...Oleksandr Nychyk; Gabriel L. Galea; Matteo Molè; Dawn Savery; Nicholas D. E. Greene; Philip Stanier; Andrew J. Copp ABSTRACT Planar cell polarity (PCP) signalling is vital for initiation of mouse neurulation, with diminished convergent extension (CE) cell movements leading to craniorachischisis...

..., suggesting that the lack of significant disease in humans heterozygous for G1 or G2 is not due to G0 rescue of G1 or G2 toxicity. Studies using additional mice (multicopy G2 and a non-isogenic G0 mouse) supported the notion that disease is largely a function of the level of risk variant APOL1 expression...

...Grant F. Marshall; Alfredo Gonzalez-Sulser; Catherine M. Abbott ABSTRACT In most mouse models of disease, the outward manifestation of a disorder can be measured easily, can be assessed with a trivial test such as hind limb clasping, or can even be observed simply by comparing the gross...

...) and amyotrophic lateral sclerosis (ALS) cases. Numerous studies have indicated the toxicity of dipeptide repeats (DPRs), which are produced via repeat-associated non-AUG (RAN) translation from the repeat expansion, and accumulate in the brain of C9FTD/ALS patients. Mouse models expressing the human C9ORF72 repeat...

...Jens Hansen; Harald von Melchner; Wolfgang Wurst ABSTRACT Gene trapping is a high-throughput approach that has been used to introduce insertional mutations into the genome of mouse embryonic stem (ES) cells. It is performed with generic gene trap vectors that simultaneously mutate and report...

... partial levels of protein expression. However, it is unclear whether long-term, global NMD attenuation is safe. We hypothesize that a degree of NMD inhibition can be safely tolerated after completion of prenatal development. To test this hypothesis, we generated a novel transgenic mouse that expresses...

... spectrometry (MS) enables accurate and reproducible proteomic profiling in multiple model organisms including the mouse. Here, we present a comprehensive mouse reference spectral library (MouseRefSWATH) that permits quantification of up to 10,597 proteins (62.2% of the mouse proteome) by SWATH-MS. We exploit...

... of the extrahepatic bile ducts (EHBDs) in newborn infants. SOX17 is a master regulator of fetal EHBD formation. In mouse Sox17 +/− BA models, SOX17 reduction causes cell-autonomous epithelial shedding together with the ectopic appearance of SOX9-positive cystic duct-like epithelia in the gallbladder walls, resulting...

....19.6.1518 Alva , J. A. , Zovein , A. C. , Monvoisin , A. , Murphy , T. , Salazar , A. , Harvey , N. L. , Carmeliet , P. and Iruela-Arispe , M. L. ( 2006 ). VE-Cadherin-Cre-recombinase transgenic mouse: a tool for lineage analysis and gene deletion in endothelial...

... transcript requires skipping four exons to generate a functional, internally truncated protein. In vivo evaluation of this multi-exon skipping, antisense-mediated therapy requires a genetically appropriate mouse model. The human and mouse γ-sarcoglycan genes are highly homologous in sequence and gene...

... preclinical modelling of glioblastoma multiforme to understand its biology and develop therapies, with a focus on mammalian model systems. Central nervous system In vitro CRISPR/Cas9 Mouse Human Xenograft GBM Cancer Brain tumour “All models are wrong, but some are useful.” – George E...

...Channabasavaiah B. Gurumurthy; Kevin C. Kent Lloyd ABSTRACT Over the past decade, new methods and procedures have been developed to generate genetically engineered mouse models of human disease. This At a Glance article highlights several recent technical advances in mouse genome manipulation...

..., fibroblasts and endothelial cells in the developing lung and gut through EMT ( Que et al., 2008 ; Wilm et al., 2005 ), the polarized abdominal CECs would also transit into mesothelial progenitor cells through EMT. Overexpression of Six4 in the CECs of cultured mouse embryos promoted ingression...

... that higher dietary fat increased fatty acid metabolic enzymes in cartilage. The findings indicate that the choice of control diets should be carefully considered in mouse osteoarthritis studies. Our study also indicates that altered cartilage metabolism might be a contributing factor to how diet and obesity...

... of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK. § Author for correspondence ( g.galea@ucl.ac.uk ) Competing interests The authors declare no competing or financial interests. 26 9 2017 28 2 2018 The PNP of mid-neurulation mouse...

... maintained. The Mouse Genome Database (MGD, http://www.informatics.jax.org), Rat Genome Database (RGD, http://rgd.mcw.edu) and Disease Ontology (DO, http://www.disease-ontology.org) projects are collaborating to augment DO, aligning and incorporating disease terms used by MGD and RGD, and improving DO...