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Keywords: Macrophages
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Journal Articles
Dis Model Mech (2022) 15 (12): dmm049753.
Published: 22 December 2022
... macrophages and microglia, and the second for spatial registration. By using this approach, differences in immune cell morphology and behavior during homeostasis as well as in response to a stab wound or two-photon-induced brain injury were observed in intact adult fish over the course of several days...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2023) 16 (5): dmm049662.
Published: 7 December 2022
...-3-(cyclohexylamino)-2,3-dihydro-1 H -inden-1-one (BCI) improved heart function and reduced cardiac fibrosis in MI rats. Mechanistic analysis revealed that BCI attenuated macrophage inflammation through NF-κB and p38 signaling, independent of DUSP6 inhibition, leading to the downregulation of various...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Dis Model Mech (2021) 14 (5): dmm044669.
Published: 1 June 2021
... of glial cells as a central regulator of functional regeneration. Additionally, we demonstrate that glial cells and macrophages contribute to functional regeneration through mechanisms involving the Jun N-terminal kinase (JNK) pathway and the Drosophila protein Draper (Drpr), characteristic of other neural...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Metabolic Disorders
Dis Model Mech (2020) 13 (1): dmm041962.
Published: 24 January 2020
...Sarah Colijn; Vijay Muthukumar; Jun Xie; Siqi Gao; Courtney T. Griffin ABSTRACT Receptor-interacting protein kinase 3 (RIPK3) was recently implicated in promoting atherosclerosis progression through a proposed role in macrophage necroptosis. However, RIPK3 has been connected to numerous other...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (1): dmm041889.
Published: 9 January 2020
...Emily E. Rosowski ABSTRACT The specific roles of the two major innate immune cell types – neutrophils and macrophages – in response to infection and sterile inflammation are areas of great interest. The larval zebrafish model of innate immunity, and the imaging capabilities it provides, is a source...
Journal Articles
Journal Articles
Dis Model Mech (2019) 12 (4): dmm037390.
Published: 5 April 2019
... to renal injury, we showed that delivery of PTBA using an esterified prodrug (UPHD25) increases the reactivation of the renal progenitor gene Pax2a , enhances dedifferentiation of RTECs, reduces Kidney injury molecule-1 (Kim-1) expression, and lowers the number of infiltrating macrophages. Further, we...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Dis Model Mech (2015) 8 (11): 1375–1388.
Published: 1 November 2015
... infection was increased upon immunosuppressant treatment. We showed for the first time that macrophages and neutrophils were readily recruited in vivo to the site of infection in an intact host and that spore phagocytosis can be observed in real-time in vivo . While exploring innate immune effector...
Includes: Supplementary data
Journal Articles