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Keywords: Inflammatory bowel diseases
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Journal Articles

Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease

In collection:
Drug Discovery , Advanced In Vitro Models
Katie Lloyd, Stamatia Papoutsopoulou, Emily Smith, Philip Stegmaier, Francois Bergey, Lorna Morris, Madeleine Kittner, Hazel England, Dave Spiller, Mike H. R. White, Carrie A. Duckworth, Barry J. Campbell, Vladimir Poroikov, Vitor A. P. Martins dos Santos, Alexander Kel, Werner Muller, D. Mark Pritchard, Chris Probert, Michael D. Burkitt, The SysmedIBD Consortium
Journal: Disease Models & Mechanisms
Dis Model Mech (2020) 13 (11): dmm044040.
https://doi.org/10.1242/dmm.044040
Published: 27 November 2020
... Pritchard; Chris Probert; Michael D. Burkitt; The SysmedIBD Consortium ABSTRACT Inflammatory bowel diseases (IBDs) cause significant morbidity and mortality. Aberrant NF-κB signalling is strongly associated with these conditions, and several established drugs influence the NF-κB signalling network to exert...
View article titled, Using systems medicine to identify a therapeutic agent with potential for repurposing in <span class="search-highlight">inflammatory</span> <span class="search-highlight">bowel</span> <span class="search-highlight">disease</span>
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Includes: Supplementary data
Journal Articles

Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice

Allison R. Rogala, Alexi A. Schoenborn, Brian E. Fee, Viviana A. Cantillana, Maria J. Joyce, Raad Z. Gharaibeh, Sayanty Roy, Anthony A. Fodor, R. Balfour Sartor, Gregory A. Taylor, Ajay S. Gulati
Journal: Disease Models & Mechanisms
Dis Model Mech (2018) 11 (2): dmm031070.
https://doi.org/10.1242/dmm.031070
Published: 7 February 2018
... colitis Inflammatory bowel diseases Crohn's disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract, which is thought to occur as a result of dysregulated host immune responses to the enteric microbiota within a genetically susceptible host ( Abraham and Cho, 2009 ; Leone...
View article titled, Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice
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Includes: Supplementary data