...Ffion R. Hammond; Amy Lewis; Zoë C. Speirs; Holly E. Anderson; Tamara Sipka; Lewis G. Williams; Mai Nguyen-Chi; Annemarie H. Meijer; Geert F. Wiegertjes; Philip M. Elks ABSTRACT Innate immune responses to inflammation and infection are complex and represent major challenges for developing much...

... results suggest that their upregulation upon aging is likely a consequence of aging, rather than a cause. NF-κB Aging Antimicrobial peptide Drosophila Host defence peptide Inflammation Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung http://dx.doi.org...

... and homeostasis, and is implicated in the pathophysiology of disease, including congenital heart disease and cardiac surgery. Improving the microbiome and reducing inflammatory metabolites may reduce systemic inflammation following cardiac surgery with cardiopulmonary bypass (CPB) to expedite recovery post...

...Zongwang Zhang; Yang Chen; Lixia Zheng; Jianyong Du; Shicheng Wei; Xiaojun Zhu; Jing-Wei Xiong ABSTRACT Acute myocardial infarction (MI) results in loss of cardiomyocytes and abnormal cardiac remodeling with severe inflammation and fibrosis. However, how cardiac repair can be achieved by timely...

... of acute respiratory distress syndrome (ARDS) in human-sized swine, which recapitulates the clinical, radiographic and histopathologic manifestations of ARDS, providing a tool to study therapies for this highly morbid lung disease. Animal model Lung Inflammation Systemic Pathophysiology...

...Sol Díaz de León-Guerrero; Jonathan Salazar-León; Karla F. Meza-Sosa; David Valle-Garcia; Diana Aguilar-León; Gustavo Pedraza-Alva; Leonor Pérez-Martínez ABSTRACT Obesity can lead to chronic inflammation in different tissues, generating insulin and leptin resistance and alterations in glucose...

...) exacerbated inflammation consistent with monocyte contributions to initiation of pathology. After removal of TAA, either acute or chronic CSF1-Fc treatment promoted liver growth, prevented progression and promoted resolution of fibrosis. Acute CSF1-Fc treatment was also anti-fibrotic and pro-regenerative...

... developmental role in the prothoracic gland. Metamorphosis Ring gland Ecdysone Tissue damage Inflammation SUMOylation National Natural Science Foundation of China http://dx.doi.org/10.13039/501100001809 The development of organisms involves internally paced, reproducible...

... responses leading to inflammatory disorders. However, what environmental factors might contribute to disease are poorly understood. Here, to overcome the lack of in vivo models suitable for screening of environmental factors, we used zebrafish reporters of intestinal inflammation. Using zebrafish, we...

... moxifloxacin reduced infection-induced lung inflammation, and the number and size of caseating necrotic granulomas. Results from this study strengthen the potential use of rapamycin and its analogs as adjunct TB therapy, and importantly underscore the utility of the C3HeB/FeJ mouse model as a preclinical tool...

... and therefore displaying compromised stress resolution did not gain body weight but developed inflammation, especially in the skin, after HFD administration. Fibroblasts emerged as potent modifiers of this differential responsiveness to HFD, as indicated by the comparison of the UPR profiles of fibroblasts...

...: understanding the aging and cancer connection . Cell Cycle Georget. Tex 10 , 4065 - 4073 . 10.4161/cc.10.23.18254 Barone , F. , Nayar , S. and Buckley , C. D. ( 2012 ). The role of non-hematopoietic stromal cells in the persistence of inflammation . Front. Immunol. 3 , 416...

... modifications of DAMPs suppress inflammation: the case for S100A8 and S100A9 . Antioxid Redox Signal. 15 , 2235 - 2248 . 10.1089/ars.2010.3641 Liu , J. , Zhang , W. , Chuang , G. C. , Hill , H. S. , Tian , L. , Fu , Y. , Moellering , D. R. and Garvey , W. T...

... hyperuricemia-related diseases. Hyperuricemia-induced autophagy and NLRP3-dependent inflammation are critically involved in the development of renal damage and, therefore, highlight the inhibition of autophagy and inflammation in search of therapeutic strategies to treat uric acid nephropathy. References...

... cells, supported parallels between chordomas, wound and inflammation. Cancerous notochordal cells interfere with differentiation of sheath cells to form chordacentra domains, leading to fusions and vertebral clefts during development. Adults displayed IVD irregularities reminiscent of degeneration...

... of AH in mice and compared the nature of liver injury in C57/BL6 wild-type (WT) versus Nrf2 −/− mice. Our data showed that both WT and Nrf2 −/− mice demonstrate robust weight loss, and an increase in serum transaminase, steatosis and hepatic inflammation when exposed to diet and ethanol...

.../high-sugar diet-induced beta cell dysfunction and inflammation in murine islets . Diabetologia   61 , 1470 - 1483 . 10.1007/s00125-018-4576-4 Hansen , H. H. , Jelsing , J. , Hansen , C. F. , Hansen , G. , Vrang , N. , Mark , M. , Klein , T. and Mayoux , E...

...Jiang-Hua Liu; Tao Yue; Zhong-Wei Luo; Jia Cao; Zi-Qi Yan; Ling Jin; Teng-Fei Wan; Ci-Jun Shuai; Zheng-Guang Wang; Yong Zhou; Ran Xu; Hui Xie ABSTRACT Improving revascularization is one of the major measures in fracture treatment. Moderate local inflammation triggers angiogenesis, whereas systemic...

.... Fibrodysplasia ossificans progressiva (FOP): an extremely rare genetic disorder characterised by heterotopic endochondral ossification at multiple sites, predominantly muscles, tendons, ligaments and fascia. Flare-up: onset of heterotopic ossification in FOP in which the underlying acute inflammation causes...

... cassette can be used to induce tissue-specific inflammation in this model after excision of the stop codon downstream of the RFP cassette. (D) When CET-PIC3 fish are crossed to a tissue-specific Cre and subsequently treated with doxycycline, there is dose-dependent induction of the cytokines in a tissue...