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Keywords: Inflammation
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Journal Articles
In collection:
Metabolic Disorders
Dis Model Mech (2022) 15 (6): dmm048936.
Published: 13 June 2022
...Sol Díaz de León-Guerrero; Jonathan Salazar-León; Karla F. Meza-Sosa; David Valle-Garcia; Diana Aguilar-León; Gustavo Pedraza-Alva; Leonor Pérez-Martínez ABSTRACT Obesity can lead to chronic inflammation in different tissues, generating insulin and leptin resistance and alterations in glucose...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2022) 15 (4): dmm049387.
Published: 19 April 2022
...) exacerbated inflammation consistent with monocyte contributions to initiation of pathology. After removal of TAA, either acute or chronic CSF1-Fc treatment promoted liver growth, prevented progression and promoted resolution of fibrosis. Acute CSF1-Fc treatment was also anti-fibrotic and pro-regenerative...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2022) 15 (1): dmm049160.
Published: 26 January 2022
... developmental role in the prothoracic gland. Metamorphosis Ring gland Ecdysone Tissue damage Inflammation SUMOylation National Natural Science Foundation of China http://dx.doi.org/10.13039/501100001809 The development of organisms involves internally paced, reproducible...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2021) 14 (12): dmm049104.
Published: 23 December 2021
... responses leading to inflammatory disorders. However, what environmental factors might contribute to disease are poorly understood. Here, to overcome the lack of in vivo models suitable for screening of environmental factors, we used zebrafish reporters of intestinal inflammation. Using zebrafish, we...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2021) 14 (10): dmm049018.
Published: 26 October 2021
... moxifloxacin reduced infection-induced lung inflammation, and the number and size of caseating necrotic granulomas. Results from this study strengthen the potential use of rapamycin and its analogs as adjunct TB therapy, and importantly underscore the utility of the C3HeB/FeJ mouse model as a preclinical tool...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2021) 14 (10): dmm049113.
Published: 18 October 2021
... and therefore displaying compromised stress resolution did not gain body weight but developed inflammation, especially in the skin, after HFD administration. Fibroblasts emerged as potent modifiers of this differential responsiveness to HFD, as indicated by the comparison of the UPR profiles of fibroblasts...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2021) 14 (8): dmm048995.
Published: 25 August 2021
.... Summary: TFAM depletion in skin fibroblasts ex vivo results in a senescent and inflammatory phenotype, providing a valuable model to investigate the role of mitochondrial dysfunction in ageing and inflammatory pathologies. TFAM Mitochondrial dysfunction Fibroblasts Inflammation Cellular...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2021) 14 (6): dmm049012.
Published: 17 June 2021
... of downregulated genes in the 6N strain revealed pathways related to overall cellular activity, DNA binding, and skeletal and neuronal development. Network analysis revealed that pathways related to cell morphology, embryonic development, cell death, cellular metabolism and inflammation were also altered by PAE...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2021) 14 (3): dmm048041.
Published: 24 March 2021
... hyperuricemia-related diseases. Hyperuricemia-induced autophagy and NLRP3-dependent inflammation are critically involved in the development of renal damage and, therefore, highlight the inhibition of autophagy and inflammation in search of therapeutic strategies to treat uric acid nephropathy. References...
Journal Articles
Dis Model Mech (2021) 14 (3): dmm047001.
Published: 19 March 2021
... cells, supported parallels between chordomas, wound and inflammation. Cancerous notochordal cells interfere with differentiation of sheath cells to form chordacentra domains, leading to fusions and vertebral clefts during development. Adults displayed IVD irregularities reminiscent of degeneration...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (12): dmm046383.
Published: 29 December 2020
... of AH in mice and compared the nature of liver injury in C57/BL6 wild-type (WT) versus Nrf2 −/− mice. Our data showed that both WT and Nrf2 −/− mice demonstrate robust weight loss, and an increase in serum transaminase, steatosis and hepatic inflammation when exposed to diet and ethanol...
Includes: Supplementary data
Journal Articles
In collection:
Metabolic Disorders
Dis Model Mech (2020) 13 (12): dmm045351.
Published: 18 December 2020
... dysfunction and inflammation in murine islets . Diabetologia   61 , 1470 - 1483 . 10.1007/s00125-018-4576-4 Hansen , H. H. , Jelsing , J. , Hansen , C. F. , Hansen , G. , Vrang , N. , Mark , M. , Klein , T. and Mayoux , E. ( 2014 ). The sodium glucose cotransporter...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (11): dmm043620.
Published: 1 December 2020
...Jiang-Hua Liu; Tao Yue; Zhong-Wei Luo; Jia Cao; Zi-Qi Yan; Ling Jin; Teng-Fei Wan; Ci-Jun Shuai; Zheng-Guang Wang; Yong Zhou; Ran Xu; Hui Xie ABSTRACT Improving revascularization is one of the major measures in fracture treatment. Moderate local inflammation triggers angiogenesis, whereas systemic...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (9): dmm046441.
Published: 21 September 2020
... on this debilitating condition and discuss approaches to solving this clinical puzzle. Bone morphogenetic protein ACVR1 Fibrodysplasia ossificans progressiva Heterotopic ossification Inflammation Skeletal bone formation, also known as osteogenesis or ossification (see Glossary of clinical terms, Box...
Journal Articles
Dis Model Mech (2020) 13 (6): dmm042556.
Published: 26 June 2020
... inflammatory diseases. Inflammation Zebrafish Beta cell Cytokines Pancreas Pro-inflammatory cytokines (PICs) are signaling molecules that are primarily produced by immune cells (including activated macrophages and T cells) that coordinate and amplify certain immune responses. Dysregulated PIC...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (5): dmm042648.
Published: 1 June 2020
..., the stratum corneum . It results from mutations in the SPINK5 gene, which codes for a kallikrein inhibitor. Uncontrolled kallikrein activity leads to premature desquamation, resulting in a severe epidermal barrier defect and subsequent life-threatening systemic infections and chronic cutaneous inflammation...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (4): dmm042564.
Published: 30 April 2020
... to live imaging of early innate immune inflammation. Expression of zfDnaJa-Pkaca in hepatocytes induces hepatomegaly and increased hepatocyte size. In addition, FLC larvae exhibit early innate immune inflammation characterized by early infiltration of neutrophils and macrophages into the liver...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (3): dmm042515.
Published: 30 March 2020
...; however, transcriptomic and immunohistochemical profiling of several markers of inflammation revealed no innate immune activation in Arx (GCG)10+7 cortex. Neither neonatal E2 hormone therapy, nor ACTH(1-24), the frontline clinical therapy for ISSX, diminished the augmented apoptosis in Arx (GCG)10+7...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (2): dmm043638.
Published: 2 March 2020
... strongly focus on myonecrosis and the associated inflammation and oxidative stress in DMD muscle, as the lack of dystrophin causes repeated bouts of myonecrosis, which are the key events that initiate the resultant severe dystropathology. We discuss the early events of intrinsic myonecrosis, along...
Journal Articles
Dis Model Mech (2019) 12 (12): dmm040642.
Published: 17 December 2019
... improvement in renal function and a significant decrease in mortality compared to Tg26 mice. Histological examination of kidneys showed that Notch4 d1 /Tg26 + mice had overall glomerular, tubulointerstitial injury and a marked decrease in interstitial inflammation. A significant decrease in the proliferating...
Includes: Supplementary data