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Keywords: Host-directed therapy
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Journal Articles
In collection:
Drug Discovery
Dis Model Mech (2021) 14 (10): dmm049018.
Published: 26 October 2021
... for evaluating host-directed therapy candidates for the treatment of TB. To circumvent the complications associated with microbial drug resistance and to mitigate Mtb-induced inflammatory damage to the host, investigational research has turned towards host-directed therapies (HDTs), some of which are already...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (3): dmm041954.
Published: 30 March 2020
... lactate metabolism is a promising approach for cancer therapy. Here, we sought to determine the importance of LDHA for tuberculosis (TB) disease progression and its potential as a target for host-directed therapy. To this end, we orally administered FX11, a known small-molecule NADH-competitive LDHA...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2014) 7 (7): 785–797.
Published: 1 July 2014
... to be mounted ( Lam et al., 2004 ; Page et al., 2013 ). Leukocyte biology Innate immunity Infectious disease Host-directed therapy Mycobacterium Salmonella Burkholderia Staphylococcus Shigella Candida © 2014. Published by The Company of Biologists Ltd 2014 This is an Open...
Includes: Supplementary data