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Keywords: Fibroblasts
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Journal Articles
Dis Model Mech (2021) 14 (8): dmm048995.
Published: 25 August 2021
... by stable depletion of TFAM in primary mouse skin fibroblasts (SK-FBs) after 4-hydroxytamoxifen (4-OHT) administration. Tfam gene deletion caused a sustained reduction in Tfam and mtDNA-encoded mRNA in Cre(+) SK-FBs cultured for low (LP) and high (HP) passages that translated into a loss of TFAM protein...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (4): dmm029447.
Published: 19 April 2018
...-associated fibroblasts, a highly abundant and heterogeneous population of cells of mesenchymal lineage. Although it is known that fibroblasts are present from the tumor's inception to the end-stage metastatic spread, their precise functional role in cancer is not fully understood. It has been suggested...
Includes: Supplementary data
Journal Articles
In collection:
Metabolic Disorders
Dis Model Mech (2017) 10 (12): 1411–1420.
Published: 1 December 2017
... cell lines and stem-cell based models all have significant biological or practical limitations. In an attempt to widen the repertoire of human cell models in which to study adipocyte-autonomous effects of relevant human genetic variants, we have undertaken direct reprogramming of skin fibroblasts...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (11): 1353–1369.
Published: 1 November 2017
... metabolism due to lowered expression of FXN . Presently, there is no effective treatment for FRDA, and biomarkers to measure therapeutic trial outcomes and/or to gauge disease progression are lacking. Peripheral tissues, including blood cells, buccal cells and skin fibroblasts, can readily be isolated from...
Includes: Supplementary data
Journal Articles
In collection:
Cancer
Dis Model Mech (2017) 10 (1): 39–52.
Published: 1 January 2017
...Zhaohui Yang; Yu-Ching Peng; Anuradha Gopalan; Dong Gao; Yu Chen; Alexandra L. Joyner ABSTRACT It is widely appreciated that reactive stroma or carcinoma-associated fibroblasts can influence epithelial tumor progression. In prostate cancer (PCa), the second most common male malignancy worldwide...
Includes: Supplementary data