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Keywords: Epidermal barrier
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Journal Articles
Dis Model Mech (2020) 13 (5): dmm042648.
Published: 1 June 2020
..., the stratum corneum . It results from mutations in the SPINK5 gene, which codes for a kallikrein inhibitor. Uncontrolled kallikrein activity leads to premature desquamation, resulting in a severe epidermal barrier defect and subsequent life-threatening systemic infections and chronic cutaneous inflammation...
Includes: Supplementary data