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Keywords: EGFR
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Journal Articles
Journal Articles
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Cancer
Dis Model Mech (2021) 14 (11): dmm049072.
Published: 15 November 2021
... of murine lung adenocarcinomas that express human mutant EGFR in the absence of a transgenic allele containing human DTR. DT enzymatic activity was required for tumor regression, and mutant EGFR -expressing tumor cells were the primary target of DT toxicity. In FVB mice, EGFR -mutant tumors upregulated...
Includes: Supplementary data