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Keywords: Development
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Journal Articles
Dis Model Mech (2022) 15 (11): dmm049593.
Published: 4 November 2022
... and ototoxic drugs. Stem cell-derived inner ear organoids break new ground for otic cultures. They contain an organised cytoarchitecture more akin to the in vivo developing ear than can be achieved in 2D monolayers, allowing for more accurate developmental recapitulation. However, the variable...
Journal Articles
In collection:
The RAS Pathway
Dis Model Mech (2022) 15 (2): dmm048887.
Published: 11 August 2021
... differentiation ( Liang et al., 2018 ). It is assumed that segregation of cells with different growth properties during development generates follicles of different size and tissue distribution in the adult gland ( Nilsson and Fagman, 2013 ). Developmental trajectories that govern follicle heterogeneity might...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (12): dmm046920.
Published: 21 December 2020
... , A. , Tracy , A. A. , Coletti , C. M. , Hila , R. , Shamia , A. , Wells , J. , Ackerman , K. G. , et al. ( 2014 ). Molecular pathogenesis of congenital diaphragmatic hernia revealed by exome sequencing, developmental data, and bioinformatics . Proc. Natl. Acad. Sci. USA   111...
Journal Articles
Dis Model Mech (2020) 13 (9): dmm044990.
Published: 28 September 2020
... −/− mice, which is a genetic BAV model with a ∼25% penetrance of the phenotype ( Lee et al., 2000 ; Fernandez et al., 2009 ; Peterson et al., 2018 ), to identify developmental processes involved in BAV-associated aortopathy. Understanding early aortic vessel formation is crucial to comprehend the risks...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (10): dmm034637.
Published: 19 October 2018
... valve have a similar developmental origin involving contributions of endothelial, neural crest and SHF lineages. Understanding the exact role of these early cell lineages during leaflet development and OFT formation may lead to more accurate patient risk stratification and improved treatment strategies...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2016) 9 (3): 347–359.
Published: 1 March 2016
... tests. We thank Evelyn Brown and Margaret Gondo for excellent technical assistance in preparing and imaging tissue samples for electron microscopy. The slow and embryonic MyHC monoclonal antibodies used in this study were developed by H. M. Blau and were obtained from the Developmental Studies Hybridoma...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (5): 429–441.
Published: 1 May 2015
... cells of the sympathetic nervous system, it could represent a cancer driven by a failure in the normal developmental programme. Understanding normal mechanisms that are involved in sympathetic noradrenergic neuron development could give insight into NB pathogenesis and might suggest new approaches...
Includes: Supplementary data