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Keywords: DOPAL
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Journal Articles
Regev Landau, Reut Halperin, Patti Sullivan, Zion Zibly, Avshalom Leibowitz, David S. Goldstein, Yehonatan Sharabi
Journal:
Disease Models & Mechanisms
Dis Model Mech (2022) 15 (1): dmm049082.
Published: 24 January 2022
... catecholamines via the vesicular monoamine transporter (VMAT) and decreased aldehyde dehydrogenase (ALDH) activity. This double hit builds up the autotoxic metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL), the focus of the catecholaldehyde hypothesis for the pathogenesis of PD. An animal model is needed...
