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Keywords: Colorectal cancer
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Journal Articles
Dis Model Mech (2023) 16 (8): dmm050240.
Published: 31 July 2023
... in Lynch syndrome (LS)-associated colorectal cancers. Here, we show that defective MMR (dMMR) interacts with acetaldehyde, in a gene/environment interaction, enhancing dMMR-driven colonic tumour formation in a LS murine model of Msh2 conditional inactivation ( Lgr5-CreER ; Msh2 flox/− , or Msh2-LS...
Includes: Supplementary data
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Dis Model Mech (2022) 15 (1): dmm049233.
Published: 11 January 2022
... genomic and transcriptomic stratification, which has improved the clinical efficacy of targeted treatments. A primary example of this is the stratification of colorectal cancer (CRC) into four consensus molecular subtypes (CMSs; Fig. 2 A) classified by their gene expression signatures, copy-number...
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Dis Model Mech (2014) 7 (11): 1215–1225.
Published: 1 November 2014
... Society for the Promotion of Science (0233639 to K.Y.). References American Cancer Society ( 2014a ). What are the Key Statistics About Colorectal Cancer? Available from http://www.cancer.org/cancer/colonandrectumcancer/detailedguide/colorectal-cancer-key-statistics , accessed on February...
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