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1-8 of 8
Keywords: Colorectal cancer
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Journal Articles
Journal:
Disease Models & Mechanisms
Dis Model Mech (2023) 16 (8): dmm050240.
Published: 31 July 2023
... in Lynch syndrome (LS)-associated colorectal cancers. Here, we show that defective MMR (dMMR) interacts with acetaldehyde, in a gene/environment interaction, enhancing dMMR-driven colonic tumour formation in a LS murine model of Msh2 conditional inactivation ( Lgr5-CreER ; Msh2 flox/− , or Msh2-LS...
Includes: Supplementary data
Journal Articles
In collection:
Cancer
Toni T. Lemmetyinen, Emma W. Viitala, Linnea Wartiovaara, Tuomas Kaprio, Jaana Hagström, Caj Haglund, Pekka Katajisto, Timothy C. Wang, Eva Domènech-Moreno, Saara Ollila
Journal:
Disease Models & Mechanisms
Dis Model Mech (2023) 16 (4): dmm049692.
Published: 3 April 2023
... in human colorectal cancer (CRC). Interestingly, high expression of stromal NRG1 was associated with improved survival in CRC cohorts, suggesting a tumor-suppressive function. Our results highlight the power of stromal NRG1 in transcriptional reprogramming and protection of the intestinal epithelium from...
Includes: Supplementary data
Journal Articles
In collection:
Cancer
Journal:
Disease Models & Mechanisms
Dis Model Mech (2022) 15 (1): dmm049233.
Published: 11 January 2022
... genomic and transcriptomic stratification, which has improved the clinical efficacy of targeted treatments. A primary example of this is the stratification of colorectal cancer (CRC) into four consensus molecular subtypes (CMSs; Fig. 2 A) classified by their gene expression signatures, copy-number...
Journal Articles
Journal:
Disease Models & Mechanisms
Dis Model Mech (2020) 13 (1): dmm043166.
Published: 24 January 2020
...Joshua R. Huot; Leah J. Novinger; Fabrizio Pin; Andrea Bonetto ABSTRACT Colorectal cancer (CRC) is often accompanied by formation of liver metastases (LM) and skeletal muscle wasting, i.e. cachexia. Despite affecting the majority of CRC patients, cachexia remains underserved, understudied...
Journal Articles
Michael Buchert, Franziska Rohde, Moritz Eissmann, Niall Tebbutt, Ben Williams, Chin Wee Tan, Alexander Owen, Yumiko Hirokawa, Alexandra Gnann, Gertraud Orend, Gayle Orner, Rod H. Dashwood, Joan K. Heath, Matthias Ernst, Klaus-Peter Janssen
Journal:
Disease Models & Mechanisms
Dis Model Mech (2015) 8 (11): 1361–1373.
Published: 1 November 2015
... in the vast majority of colorectal cancers. However, the outcome of the disease varies markedly from individual to individual, even within the same tumor stage. This heterogeneity is governed to a great extent by the genetic make-up of individual tumors and the combination of oncogenic mutations. In order...
Includes: Supplementary data
Journal Articles
Benjamin B. Williams, Niall C. Tebbutt, Michael Buchert, Tracy L. Putoczki, Karen Doggett, Shisan Bao, Cameron N. Johnstone, Frederick Masson, Frederic Hollande, Antony W. Burgess, Andrew M. Scott, Matthias Ernst, Joan K. Heath
Journal:
Disease Models & Mechanisms
Dis Model Mech (2015) 8 (8): 805–815.
Published: 1 August 2015
... with colorectal carcinoma . EJNMMI Res. 4 , 22 . 10.1186/s13550-014-0022-x Eaden , J. A. , Abrams , K. R. and Mayberry , J. F. ( 2001 ). The risk of colorectal cancer in ulcerative colitis: a meta-analysis . Gut 48 , 526 - 535 . 10.1136/gut.48.4.526 Ernst , M. , Preaudet...
Includes: Supplementary data
Journal Articles
Amy A. Irving, Kazuto Yoshimi, Marcia L. Hart, Taybor Parker, Linda Clipson, Madeline R. Ford, Takashi Kuramoto, William F. Dove, James M. Amos-Landgraf
Journal:
Disease Models & Mechanisms
Dis Model Mech (2014) 7 (11): 1215–1225.
Published: 1 November 2014
... Society for the Promotion of Science (0233639 to K.Y.). References American Cancer Society ( 2014a ). What are the Key Statistics About Colorectal Cancer? Available from http://www.cancer.org/cancer/colonandrectumcancer/detailedguide/colorectal-cancer-key-statistics , accessed on February...
Journal Articles
Peter J. Belmont, Eva Budinska, Ping Jiang, Mark J. Sinnamon, Erin Coffee, Jatin Roper, Tao Xie, Paul A. Rejto, Sahra Derkits, Owen J. Sansom, Mauro Delorenzi, Sabine Tejpar, Kenneth E. Hung, Eric S. Martin
Journal:
Disease Models & Mechanisms
Dis Model Mech (2014) 7 (6): 613–623.
Published: 1 June 2014
...Peter J. Belmont; Eva Budinska; Ping Jiang; Mark J. Sinnamon; Erin Coffee; Jatin Roper; Tao Xie; Paul A. Rejto; Sahra Derkits; Owen J. Sansom; Mauro Delorenzi; Sabine Tejpar; Kenneth E. Hung; Eric S. Martin Effective treatment options for advanced colorectal cancer (CRC) are limited, survival rates...
Includes: Supplementary data
