... work is properly attributed. Summary: Unconstrained tissue repair can lead to cancer. We explore how NOTCH signalling promotes ductular regeneration while asking whether it can be inhibited to limit tumour growth. Bile duct Cancer Liver NOTCH Cancer Research UK http...

...Julián Cerón ABSTRACT After decades of research, our knowledge of the complexity of cancer mechanisms, elegantly summarized as ‘hallmarks of cancer’, is expanding, as are the therapeutic opportunities that this knowledge brings. However, cancer still needs intense research to diminish its...

...Dale A. Begley; Debra M. Krupke; John P. Sundberg; Emily L. Jocoy; Joel E. Richardson; Steven B. Neuhauser; Carol J. Bult ABSTRACT The laboratory mouse has served for decades as an informative animal model system for investigating the genetic and genomic basis of cancer in humans. Although...

...Ateequllah Hayat; Edward P. Carter; Hamish W. King; Aysegul Ors; Aaron Doe; Saul A. Teijeiro; Sarah Charrot; Susana Godinho; Pedro Cutillas; Hisham Mohammed; Richard P. Grose; Gabriella Ficz ABSTRACT Overexpression of the HER2 protein in breast cancer patients is a predictor of poor prognosis...

...Thanh T. Le; Madeleine J. Oudin ABSTRACT The peripheral nervous system plays an important role in cancer progression. Studies in multiple cancer types have shown that higher intratumoral nerve density is associated with poor outcomes. Peripheral nerves have been shown to directly regulate tumor...

...Nicholas E. Baker; Cristina Montagna ABSTRACT Aneuploidy, the gain or loss of chromosomes, is the cause of birth defects and miscarriage and is almost ubiquitous in cancer cells. Mosaic aneuploidy causes cancer predisposition, as well as age-related disorders. Despite the cell-intrinsic mechanisms...

... models in basic biology and efficacy testing has been cited as a potential cause of failure in clinical trials. We developed and characterized five diverse RAG1 null mouse strains as models that allow xenografts to grow. In these strains, we characterized the growth of breast cancer, leukemia and glioma...

... potential for studying melanocyte development in vivo . Zebrafish Cancer Melanoma Electroporation Spitz neoplasm National Heart, Lung, and Blood Institute http://dx.doi.org/10.13039/100000050 T32 HL007627 National Cancer Institute http://dx.doi.org/10.13039/100000054...

...Jun Nakayama; Hiroko Matsunaga; Koji Arikawa; Takuya Yoda; Masahito Hosokawa; Haruko Takeyama; Yusuke Yamamoto; Kentaro Semba ABSTRACT Gene expression analysis at the single-cell level by next-generation sequencing has revealed the existence of clonal dissemination and microheterogeneity in cancer...

...Courtney Choutka; Cecilia Cabrera; Susumu Hirabayashi ABSTRACT Cancer continues to be a leading cause of death worldwide, largely due to metastases and cachexia. It is a complex disease that is commonly associated with a variety of comorbidities. With global increases in ageing populations...

...Donita C. Brady; Julija Hmeljak; Arvin C. Dar ABSTRACT Several cancers and rare genetic diseases are caused by dysregulation in the RAS signaling pathway. RAS proteins serve as molecular switches that regulate pathways involved in cellular growth, differentiation and survival. These pathways have...

...Salvador Alonso; Lukas E. Dow ABSTRACT The identification of large chromosomal rearrangements in cancers has multiplied exponentially over the last decade. These complex and often rare genomic events have traditionally been challenging to study, in part owing to lack of tools that efficiently...

...Elin Schoultz; Ellen Johansson; Carmen Moccia; Iva Jakubikova; Naveen Ravi; Shawn Liang; Therese Carlsson; Mikael Montelius; Konrad Patyra; Jukka Kero; Kajsa Paulsson; Henrik Fagman; Martin O. Bergo; Mikael Nilsson ABSTRACT Cancer cells hijack developmental growth mechanisms but whether tissue...

... , A. G. , Bonilla , F. and Muñoz , A. ( 2005 ). The Wnt antagonist DICKKOPF-1 gene is a downstream target of β-catenin/TCF and is downregulated in human colon cancer . Oncogene 24 , 1098 - 1103 . 10.1038/sj.onc.1208303 Harada , N. , Tamai , Y. , Ishikawa , T.-O...

... the latter's remoteness from the mutation site. We hypothesize that the Arg230His SDHB mutation rewires metabolism, reminiscent of metabolic reprogramming in cancer. Our tractable model provides a novel tool to investigate the metastatic propensity of this familial cancer and our approach could illuminate...

...Ketu Mishra-Gorur; Daming Li; Xianjue Ma; Yanki Yarman; Lei Xue; Tian Xu ABSTRACT Targeted cell migration plays important roles in developmental biology and disease processes, including in metastasis. Drosophila tumors exhibit traits characteristic of human cancers, providing a powerful model...

...Faye L. Robertson; Maria-Angeles Marqués-Torrejón; Gillian M. Morrison; Steven M. Pollard ABSTRACT Glioblastoma multiforme (GBM) is one of the deadliest human cancers. Despite increasing knowledge of the genetic and epigenetic changes that underlie tumour initiation and growth, the prognosis...

...Gianluca D'Agati; Elena María Cabello; Karl Frontzek; Elisabeth J. Rushing; Robin Klemm; Mark D. Robinson; Richard M. White; Christian Mosimann; Alexa Burger ABSTRACT The aberrant activation of developmental processes triggers diverse cancer types. Chordoma is a rare, aggressive tumor arising from...

...Emma Brown; Joanna Brunker; Sarah E. Bohndiek ABSTRACT The tumour microenvironment (TME) is a complex cellular ecosystem subjected to chemical and physical signals that play a role in shaping tumour heterogeneity, invasion and metastasis. Studying the roles of the TME in cancer progression would...

... it to take 100 years for this model to be fully accredited? This Special Article summarises the efforts and achievements of Drosophilists to establish the fly as a valid model in cancer research through different scientific periods. * Author for correspondence ( svillegas@umh.es ) Competing...