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Keywords: Cancer
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Journal Articles
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Cancer
Dis Model Mech (2021) 14 (9): dmm049078.
Published: 29 September 2021
...Salvador Alonso; Lukas E. Dow ABSTRACT The identification of large chromosomal rearrangements in cancers has multiplied exponentially over the last decade. These complex and often rare genomic events have traditionally been challenging to study, in part owing to lack of tools that efficiently...
Journal Articles
Dis Model Mech (2022) 15 (2): dmm048887.
Published: 11 August 2021
...Elin Schoultz; Ellen Johansson; Carmen Moccia; Iva Jakubikova; Naveen Ravi; Shawn Liang; Therese Carlsson; Mikael Montelius; Konrad Patyra; Jukka Kero; Kajsa Paulsson; Henrik Fagman; Martin O. Bergo; Mikael Nilsson ABSTRACT Cancer cells hijack developmental growth mechanisms but whether tissue...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2021) 14 (1): dmm046706.
Published: 15 January 2021
... models are Cre and Flp ( Sadowski, 1995 ; Sternberg and Hamilton, 1981 ). Historically, most cancer-associated conditional alleles contain pairs of loxP sites for Cre-driven recombination: e.g. Tp53 flox2-10 ( Marino et al., 2000 ), Apc flox ( Cheung et al., 2009 ) and Ctnnb1 flox(ex3) ( Harada...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (10): dmm044925.
Published: 15 October 2020
... the latter's remoteness from the mutation site. We hypothesize that the Arg230His SDHB mutation rewires metabolism, reminiscent of metabolic reprogramming in cancer. Our tractable model provides a novel tool to investigate the metastatic propensity of this familial cancer and our approach could illuminate...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (10): dmm039727.
Published: 07 October 2019
...Ketu Mishra-Gorur; Daming Li; Xianjue Ma; Yanki Yarman; Lei Xue; Tian Xu ABSTRACT Targeted cell migration plays important roles in developmental biology and disease processes, including in metastasis. Drosophila tumors exhibit traits characteristic of human cancers, providing a powerful model...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (9): dmm040386.
Published: 06 September 2019
...Faye L. Robertson; Maria-Angeles Marqués-Torrejón; Gillian M. Morrison; Steven M. Pollard ABSTRACT Glioblastoma multiforme (GBM) is one of the deadliest human cancers. Despite increasing knowledge of the genetic and epigenetic changes that underlie tumour initiation and growth, the prognosis...
Journal Articles
Dis Model Mech (2019) 12 (7): dmm039636.
Published: 16 July 2019
...Emma Brown; Joanna Brunker; Sarah E. Bohndiek ABSTRACT The tumour microenvironment (TME) is a complex cellular ecosystem subjected to chemical and physical signals that play a role in shaping tumour heterogeneity, invasion and metastasis. Studying the roles of the TME in cancer progression would...
Journal Articles
Dis Model Mech (2019) 12 (7): dmm039545.
Published: 16 July 2019
...Gianluca D'Agati; Elena María Cabello; Karl Frontzek; Elisabeth J. Rushing; Robin Klemm; Mark D. Robinson; Richard M. White; Christian Mosimann; Alexa Burger ABSTRACT The aberrant activation of developmental processes triggers diverse cancer types. Chordoma is a rare, aggressive tumor arising from...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (4): dmm039032.
Published: 01 April 2019
... it to take 100 years for this model to be fully accredited? This Special Article summarises the efforts and achievements of Drosophilists to establish the fly as a valid model in cancer research through different scientific periods. * Author for correspondence ( svillegas@umh.es ) Competing...
Journal Articles
Dis Model Mech (2019) 12 (3): dmm038919.
Published: 01 March 2019
...Harold Varmus Harold Varmus has made pioneering contributions to our understanding of cancer as a genetic disease. The discovery of the cellular origin of retroviral oncogenes earned him and his long-term collaborator, Michael Bishop, the Lasker Prize for Basic Medical Sciences in 1982...
Journal Articles
Dis Model Mech (2018) 11 (11): dmm037366.
Published: 16 November 2018
...Robert E. Hynds; Elina Vladimirou; Sam. M. Janes ABSTRACT The extent of genetic and epigenetic diversity between and within patient tumors is being mapped in ever more detail. It is clear that cancer is an evolutionary process in which tumor cell intrinsic and extrinsic forces shape clonal...
Journal Articles
Dis Model Mech (2018) 11 (9): dmm034561.
Published: 27 September 2018
...Scott J. Callahan; Stephanie Tepan; Yan M. Zhang; Helen Lindsay; Alexa Burger; Nathaniel R. Campbell; Isabella S. Kim; Travis J. Hollmann; Lorenz Studer; Christian Mosimann; Richard M. White ABSTRACT Transgenic animals are invaluable for modeling cancer genomics, but often require complex crosses...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (8): dmm035758.
Published: 07 August 2018
...Alexander Muir; Laura V. Danai; Matthew G. Vander Heiden ABSTRACT Cancers have an altered metabolism, and there is interest in understanding precisely how oncogenic transformation alters cellular metabolism and how these metabolic alterations can translate into therapeutic opportunities...
Journal Articles
Dis Model Mech (2018) 11 (8): dmm034272.
Published: 02 August 2018
... of metabolic by-products. However, cancer cells can modulate metabolic pathways and thus adapt to specific nutrients. Unlike tumor cells, immune cells are not subject to a ‘micro-evolution’ that would allow them to adapt to progressing tumors that continuously develop new mechanisms of immune escape...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (8): dmm032920.
Published: 03 May 2018
...Gloria Pascual; Diana Domínguez; Salvador Aznar Benitah; Almut Schulze; Mariia Yuneva ABSTRACT Metastasis remains the leading cause of cancer-related deaths worldwide, and our inability to identify the tumour cells that colonize distant sites hampers the development of effective anti-metastatic...
Journal Articles
Dis Model Mech (2018) 11 (4): dmm029447.
Published: 19 April 2018
...Valerie S. LeBleu; Raghu Kalluri ABSTRACT In malignant tumors, cancer cells adapt to grow within their host tissue. As a cancer progresses, an accompanying host stromal response evolves within and around the nascent tumor. Among the host stromal constituents associated with the tumor are cancer...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (3): dmm033100.
Published: 16 March 2018
...Jelle J. F. Sleeboom; Hossein Eslami Amirabadi; Poornima Nair; Cecilia M. Sahlgren; Jaap M. J. den Toonder ABSTRACT Most cancer deaths are not caused by the primary tumor, but by secondary tumors formed through metastasis, a complex and poorly understood process. Cues from the tumor...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (1): dmm032375.
Published: 29 January 2018
... using a classical pharmacological approach. Curcumin, the main curcuminoid of turmeric, is a complex molecule possessing wide-ranging biological activities, cellular mechanisms and roles in potential therapeutic treatment, including Alzheimer's disease and cancer. Here, we investigate the physiological...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (1): dmm031146.
Published: 17 January 2018
...) in the imaginal disc. Further evidence comes from cell culture studies, in which we expressed Drosophila Hipk in human breast cancer cells and showed that it enhances proliferation and migration. Past studies have shown that Hipk can promote the action of conserved pathways implicated in cancer and EMT...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (10): 1201–1209.
Published: 01 October 2017
...Shilin Song; Héctor Herranz; Stephen M. Cohen ABSTRACT Switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complexes are mutated in many human cancers. In this article, we make use of a Drosophila genetic model for epithelial tumor formation to explore the tumor suppressive role of SWI...
Includes: Supplementary data