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Keywords: Brain development
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Journal Articles
Dis Model Mech (2021) 14 (6): dmm049012.
Published: 17 June 2021
... also revealed that the biological functions affected by alcohol in the 6J mice differed from those identified in the 6N mice. Gene expression pathways related to cell proliferation, apoptosis, and those controlling craniofacial and brain development were affected in the 6J embryos. In contrast...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (9): dmm046243.
Published: 25 September 2020
... from embryos frozen within ten generations after the colony was first created in 2010. Through quantification of prenatal and postnatal brain development and several behavioral tasks, our results provide a comprehensive comparison of Ts65Dn across time and show a significant amount of variability both...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (3): dmm037762.
Published: 8 March 2019
...Laura E. Kuil; Nynke Oosterhof; Samuël N. Geurts; Herma C. van der Linde; Erik Meijering; Tjakko J. van Ham ABSTRACT Microglia are brain-resident macrophages, which have specialized functions important in brain development and in disease. They colonize the brain in early embryonic stages, but few...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (12): dmm035931.
Published: 19 December 2018
.... There is an expanding literature addressing the function of αDG in the nervous system, with recent reports demonstrating important roles in brain development and in the maintenance of neuronal synapses. Much of these data are derived from an increasingly rich array of experimental animal models. This Review aims...
Journal Articles
Dis Model Mech (2018) 11 (6): dmm031013.
Published: 12 June 2018
... and adults. Altogether, our data showed widespread and unexpected fundamental differences in behavioral, gene expression and brain development phenotypes between these three mouse models. Our findings illustrate unique limitations of each model when studying aspects of brain development and function in DS...
Includes: Supplementary data