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Keywords: Brain
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Journal Articles
Dis Model Mech (2022) 15 (3): dmm049291.
Published: 3 March 2022
...Abbe H. Crawford; John C. W. Hildyard; Sophie A. M. Rushing; Dominic J. Wells; Maria Diez-Leon; Richard J. Piercy ABSTRACT Duchenne muscular dystrophy (DMD), a fatal musculoskeletal disease, is associated with neurodevelopmental disorders and cognitive impairment caused by brain dystrophin...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2022) 15 (1): dmm049187.
Published: 26 January 2022
...Karissa Barthelson; Morgan Newman; Michael Lardelli ABSTRACT Energy production is the most fundamentally important cellular activity supporting all other functions, particularly in highly active organs, such as brains. Here, we summarise transcriptome analyses of young adult (pre-disease) brains...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (2): dmm041319.
Published: 12 December 2019
... preclinical testing in large animal models. The minipig is a suitable experimental animal because of its large gyrencephalic brain, body weight of 70-100 kg, long lifespan, and anatomical, physiological and metabolic resemblance to humans. The Libechov transgenic minipig model for HD (TgHD) has proven useful...
Journal Articles
Dis Model Mech (2019) 12 (11): dmm040683.
Published: 14 November 2019
... the small GTPase Rac1 is conditionally ablated in the (non-neural) surface ectoderm. Most mutant fetuses have open spina bifida, and some also exhibit exencephaly/anencephaly. However, a proportion of mutant fetuses exhibit brain herniation, affecting the occipito-parietal region and closely resembling...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (5): dmm039180.
Published: 13 May 2019
... phenotypes at the (sub)cellular, brain and behavioral levels, and discuss strategies of how this extraordinarily efficient and versatile model can contribute to ‘next generation’ medical genomics and to a better understanding of these disorders. Also for FXS research, Drosophila continues to reveal...
Journal Articles
Dis Model Mech (2018) 11 (7): dmm033258.
Published: 10 July 2018
.... ( 2004 ). Anchoring of aquaporin-4 in brain: molecular mechanisms and implications for the physiology and pathophysiology of water transport . Neuroscience   129 , 999 - 1010 . 10.1016/j.neuroscience.2004.08.049 Anderson , J. L. , Head , S. I. and Morley , J. W. ( 2003...
Journal Articles
Dis Model Mech (2014) 7 (7): 857–869.
Published: 1 July 2014
...Tjakko J. van Ham; Colleen A. Brady; Ruby D. Kalicharan; Nynke Oosterhof; Jeroen Kuipers; Anneke Veenstra-Algra; Klaas A. Sjollema; Randall T. Peterson; Harm H. Kampinga; Ben N. G. Giepmans Many brain diseases involve activation of resident and peripheral immune cells to clear damaged and dying...
Includes: Supplementary data