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Keywords: Autophagy
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Journal Articles
In collection:
Stem Cells
Dis Model Mech (2022) 15 (12): dmm049471.
Published: 15 December 2022
... but not that of p38 or ERK1/2. Furthermore, vincristine-treatment resulted in impaired autophagy and reduced autophagic flux. Rapamycin-treatment reversed the effect of impaired autophagy and JNK activation. These results not only established a platform to study peripheral degeneration of human neurons but also...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
Dis Model Mech (2022) 15 (10): dmm049785.
Published: 12 October 2022
... exocyst activity, urothelial cell death and subsequent ureter obstruction was unclear. Here, we report that inhibited urothelial stratification does not drive cell death during ureter development. Instead, we demonstrate that the exocyst plays a critical role in autophagy in urothelial cells...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2022) 15 (3): dmm049247.
Published: 28 March 2022
... (CSE) in submerged or air–liquid interface conditions. Abundance of key regulators controlling mitochondrial biogenesis, mitophagy and mitochondrial dynamics was assessed. Acute exposure to WCS or CSE increased the abundance of components of autophagy and receptor-mediated mitophagy in all models...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2022) 15 (1): dmm049345.
Published: 31 January 2022
...Heidi Zinecker; Anna Katharina Simon ABSTRACT Autophagy, as the key nutrient recycling pathway, enables eukaryotic cells to adapt to surging cellular stress during aging and, thereby, delays age-associated deterioration. Autophagic flux declines with age and, in turn, decreases in autophagy...
Journal Articles
In collection:
Metabolic Disorders
Dis Model Mech (2021) 14 (12): dmm049173.
Published: 24 December 2021
.... As a NAFLD model, we used apolipoprotein E-deficient mice administered a high-fat diet for 8 or 18 weeks. We demonstrated that insulin resistance and decreased lipogenesis and autophagy observed after 18 weeks on the diet are related to a concerted regulation carried out by miR-26b-5p, miR-34a-5p, miR-149-5p...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2021) 14 (3): dmm048041.
Published: 24 March 2021
... in survival rate. Architecture and function of the kidneys in UOX -KO rats were impaired. Injury to the kidney resulted in increased interstitial fibrosis, macrophage infiltration, increased expression of NLRP3 and IL-1β, and activation of multiple cell-signaling pathways associated with autophagy...
Journal Articles
Dis Model Mech (2020) 13 (2): dmm041244.
Published: 10 January 2020
...-Rus; James Dowling; Maaike van Putten ABSTRACT X-linked myopathy with excessive autophagy (XMEA) is a genetic disease associated with weakness of the proximal muscles. It is caused by mutations in the VMA21 gene, coding for a chaperone that functions in the vacuolar ATPase (v-ATPase) assembly...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (2): dmm036681.
Published: 22 February 2019
... curative treatments. Autophagy has been considered a promising therapeutic target because the absence of VPS13A causes a defective autophagy flux. However, the mechanistic details of this deficiency are unknown. Here, we identified Rab7A as an interactor of one of the VPS13 family members in Dictyostelium...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (2): dmm033803.
Published: 7 February 2019
... in cellular reactive oxygen species, which, in turn, triggers proteasomal degradation. ALS Autophagy UPS Aggregate Rapamycin MG132 Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disease characterized by loss of motor neurons, resulting in muscular atrophy...
Includes: Supplementary data
Journal Articles
In collection:
Metabolic Disorders
Dis Model Mech (2018) 11 (9): dmm032698.
Published: 16 August 2018
... and photoreceptor degeneration, decreased mitochondrial activity, increased levels of reactive oxygen species, decreased autophagy dynamics/flux, and increased inflammatory response in the RPE and retina. Our study shows that Pgc -1α is important in outer retina biology and that Pgc -1α +/− mice fed with HFD...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (2): dmm032151.
Published: 26 February 2018
.... Following T3SS-mediated invasion of epithelial cells, a number of host cell mechanisms recruit the autophagy machinery to Shigella , including the NLRs NOD1 and NOD2 that detect bacterial peptidoglycan (see Glossary, Box 1 ) in the cytosol (reviewed in Krokowski and Mostowy, 2016 ; Keestra-Gounder...
Journal Articles
Dis Model Mech (2017) 10 (5): 645–654.
Published: 1 May 2017
... of DSBs was dependent on autophagy, which was initialized by an increase of phosphorylated (p)AMPK, and blocked by the class III phosphoinositide 3-kinase (PI3K) and autophagy inhibitor 3-methyladenine (3MeA). ALS-hMSC death in response to DSBs was not apoptotic as it was caspase independent. This unique...
Journal Articles
Dis Model Mech (2016) 9 (9): 965–974.
Published: 1 September 2016
... a crucial role of autophagy in immunity and inflammation. Keeping in mind this close relationship, we aimed to decipher these processes in the context of the defects that occur during ageing in the retina of Igf1 −/− mice. Tnfa and Il1b mRNAs, and phosphorylation of JNK and p38 MAPK were elevated...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2016) 9 (5): 501–512.
Published: 1 May 2016
...Péter Nagy; Laura Kovács; Gyöngyvér O. Sándor; Gábor Juhász ABSTRACT UV radiation resistance-associated gene (UVRAG) is a tumor suppressor involved in autophagy, endocytosis and DNA damage repair, but how its loss contributes to colorectal cancer is poorly understood. Here, we show that UVRAG...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (8): 977–987.
Published: 1 August 2015
... of autophagy in retinas of the EMB-intraperitoneal (IP)-injected rat model. We further demonstrated that exposure to EMB induces autophagosome accumulation, which results from the impaired autophagic flux that is mediated by a PKCδ-dependent pathway, inhibits the PI3K/Akt/mTOR signaling pathway and leads...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (7): 679–690.
Published: 1 July 2015
...-shock induced expression of 480 CUG repeats in adult flies resulted in a reduction in the area of the indirect flight muscles. In these model flies, reduction of muscle area was concomitant with increased apoptosis and autophagy. Inhibition of apoptosis or autophagy mediated by the overexpression...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2014) 7 (12): 1351–1363.
Published: 1 December 2014
... to defects in the endolysosomal and autophagy pathways, raising the question of whether endogenous LRRK2 might play a role in these processes. Here, we report the characterization of multiple novel ethyl methanesulfonate (EMS)-induced nonsense alleles in the Drosophila LRRK2 homolog, lrrk . Using...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2014) 7 (4): 411–419.
Published: 1 April 2014
... distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. α1-antitrypsin deficiency Autophagy Liver disease...