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Keywords: Arrhythmia
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Journal Articles
Dis Model Mech (2023) 16 (5): dmm050101.
Published: 17 May 2023
... cause complex cardiac arrhythmias that can manifest as severe sinus bradycardia, sinus arrest, chronotropic incompetence and increased susceptibility to atrial fibrillation, among other cardiac conditions. SND has a complex aetiology, with both pre-existing disease and heritable genetic variation...
Journal Articles
Dis Model Mech (2020) 13 (7): dmm044727.
Published: 20 July 2020
... knockdown of Drosophila orthologs of CCR4-NOT genes in vivo ( CNOT1/N ot1 and CNOT7/8/Pop2 ) was either lethal or resulted in dilated cardiomyopathy, reduced contractility or a propensity for arrhythmia. Silencing CNOT2/Not2 , CNOT4/ N ot4 and CNOT6/6L/twin also affected cardiac chamber size...
Includes: Supplementary data
Journal Articles
In collection:
Stem Cells
Dis Model Mech (2018) 11 (2): dmm032896.
Published: 26 February 2018
... activity in young patients. However, the mechanism causing SCD as a result of exercise remains unknown, but exercise-induced ventricular arrhythmias are thought to be responsible for this fatal consequence. To understand the disease mechanism behind HCM in a better way, we generated patient-specific...
Includes: Supplementary data
Journal Articles