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Keywords: Apoptosis
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Journal Articles
Dis Model Mech (2023) 16 (5): dmm049786.
Published: 7 November 2022
... disease. One such multifunctional candidate for drug targeting is the acetyltransferase Tip60, which is known to acetylate both histone and non-histone protein targets that have been shown in cancer cells to promote apoptosis and to initiate the DNA damage response, thereby limiting cellular expansion...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2022) 15 (3): dmm049234.
Published: 16 March 2022
... in tissues with reduced Nup98-96, counteracted by elevated apoptosis and aberrant signaling associated with chronic wounding. Reducing Nup98-96 function led to defects in protein synthesis that triggered JNK signaling and contributed to hallmarks of tumorigenesis when apoptosis was inhibited. We suggest...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2021) 14 (6): dmm049012.
Published: 17 June 2021
... signaling and apoptosis related to the downregulated genes ( Table S3 ). The top ten de novo networks were related to cell death, intercellular signaling, nutrient metabolism and embryonic development ( Table S2B ). At E7.5, functional profiling of the upregulated genes indicated increased prostaglandin...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (12): dmm046375.
Published: 18 December 2020
... function was depressed as determined by echocardiography. On Day 5, peaks of apoptosis and expression of DDR-regulatory genes were observed, highlighted by >25-fold increased expression of Brca1 . Concomitantly, the expression of genes encoding cyclin-A2, cyclin-B2 and cyclin-dependent kinase 1, which...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (10): dmm045807.
Published: 30 October 2020
... of replicative stress and accumulated endogenous DNA damage that was accompanied by stabilization of TRP53. Notably, inactivation of Trp53 prevented apoptosis of Atrip -deficient progenitor cells and was sufficient to rescue retinal dysplasia, neurodegeneration and loss of vision. Together, these results reveal...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (6): dmm043174.
Published: 26 June 2020
... malfunction. Expression of the two most pathogenic variants, Prp8 S>F and Prp8 H>R , induced apoptosis causing alterations to the adult eye morphology. The affected tissue mounted stress and cytoprotective responses, while genetic programs underlying neuronal function were attenuated. Importantly...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (11): dmm040352.
Published: 22 November 2019
...), resulting in the activation of pro-apoptotic cascades that lead to cell death. Here, we identified Bax inhibitor 1 (BI-1), an evolutionarily conserved protein encoded by the transmembrane BAX inhibitor motif-containing 6 ( TMBIM6 ) gene, as a novel modulator of ER-stress-induced apoptosis after HI brain...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (10): dmm040279.
Published: 4 October 2019
...). Disruption of Sox10 expression was also observed at E10.5 in the maxillary component of the first branchial arch, which gives rise to secondary palatal shelves. Moreover, we found significant elevation of CNCC apoptosis in RA-treated embryos. RNA-sequencing comparisons of RA-treated embryos compared...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (5): dmm035790.
Published: 7 May 2019
... technology. Here, we show that homozygous loss of asxl1 leads to apoptosis of newly formed HSCs. Apoptosis occurred via the mitochondrial apoptotic pathway mediated by upregulation of bim and bid . Half of the asxl1 +/ − zebrafish had myeloproliferative neoplasms (MPNs) by 5 months of age. Heterozygous loss...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (2): dmm031583.
Published: 26 February 2018
... defects in whole-animal systems. Here, we use zebrafish mutants to show that loss of spliceosomal components, including splicing factor 3b, subunit 1 ( sf3b1 ), causes increased DNA double-strand breaks and apoptosis in embryonic neurons. Moreover, these mutants show a concomitant accumulation of R-loops...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (10): 1217–1227.
Published: 1 October 2017
... vertebrate model to explore the signaling pathways of human adult cardiomyopathy. Hyperglycemia was induced by alternately immersing adult zebrafish in a glucose solution or water. The hyperglycemic fish gradually exhibited some hallmarks of cardiomyopathy such as myocardial hypertrophy and apoptosis...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (8): 1027–1038.
Published: 1 August 2017
... in Drosophila results in shortened lifespan, locomotor defects and apoptosis ( Sang and Jackson, 2005 ; Lu and Vogel, 2009 ). By contrast, expression of wild-type versions of these human ND proteins typically has little or no effect. These, and many other observations, support the conclusion that Drosophila...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (8): 993–1003.
Published: 1 August 2017
... disruption of external eye morphology and of the underlying retina. Furthermore, expression of (CCUG) 106 in developing retinae caused a strong apoptotic response. Inhibition of apoptosis rescued the retinal disruption in (CCUG) 106 flies. Finally, we tested two chemical compounds that have shown therapeutic...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (6): 787–796.
Published: 1 June 2017
...Syed Suhail Andrabi; Suhel Parvez; Heena Tabassum ABSTRACT Organelle damage and increases in mitochondrial permeabilization are key events in the development of cerebral ischemic tissue injury because they cause both modifications in ATP turnover and cellular apoptosis/necrosis. Early restoration...
Journal Articles
Dis Model Mech (2016) 9 (7): 799–809.
Published: 1 July 2016
..., its regulatory mechanisms remain largely undetermined. Endoplasmic reticulum stress (ER stress) plays an important role in a number of liver diseases. This study aimed to investigate whether PPARα activation inhibits ER stress-induced hepatocyte apoptosis, thereby protecting against ALF. In a murine...
Includes: Supplementary data
Journal Articles
In collection:
Metabolic Disorders
Dis Model Mech (2016) 9 (5): 573–583.
Published: 1 May 2016
... cell death and activation of caspase-8 and -3 in the hypothalamus. Regulators of apoptosis such as FADD, Bcl-2, Bcl-xL and p53 were also increased, whereas p-IκB and c-FLIP L were decreased. This was accompanied by increased levels of Nox-4 and catalase, enzymes involved in oxidative stress. In summary...
Journal Articles
Dis Model Mech (2015) 8 (12): 1491–1494.
Published: 1 December 2015
.... In this interview, he describes his career path, highlighting the shift in his research focus from the basic principles of apoptosis to clonal evolution in cancer, and also explains why Drosophila provides a powerful model system for studying cancer biology. © 2015. Published by The Company of Biologists Ltd...
Journal Articles
Dis Model Mech (2015) 8 (12): 1603–1614.
Published: 1 December 2015
... programmed cell death in Drosophila oogenesis . Cell Death Differ.   19 , 1069 - 1079 . 10.1038/cdd.2011.200 Sarkissian , T. , Timmons , A. , Arya , R. , Abdelwahid , E. and White , K. ( 2014 ). Detecting apoptosis in Drosophila tissues and cells . Methods   68 , 89 - 96...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (8): 977–987.
Published: 1 August 2015
...-induced activation of caspase-3 and the subsequent apoptosis of RGC-5 cells. Western blot analysis revealed that the expression levels of class III PI3K, Beclin-1, p62 and LC3-II were upregulated, and LC3 immunostaining results showed activation of the early phase and inhibition of the late stage...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (7): 679–690.
Published: 1 July 2015
...-shock induced expression of 480 CUG repeats in adult flies resulted in a reduction in the area of the indirect flight muscles. In these model flies, reduction of muscle area was concomitant with increased apoptosis and autophagy. Inhibition of apoptosis or autophagy mediated by the overexpression...
Includes: Supplementary data