Issues

Drosophila Collection: Ross Cagan spoke to Gerry Rubin about his career path and the story behind some of his key breakthroughs, as well as his unique and successful approach to management and mentorship.

Drosophila Collection: Studies in Drosophila hold the potential to transform our understanding of the genetics of diabetes. We review important findings and provide a framework for diabetes gene discovery in the fly.

Drosophila Collection: A new Drosophila model of ALD reveals dysregulation of fatty acid metabolism as causal of neurodegenerative pathologies and has led to the identification of a new candidate gene for ALD in humans.

Editors' choice: Generation and characterization of a novel neural crest EMT reporter for rapid in vivo drug screening in zebrafish that identifies a small-molecule EMT inhibitor that blocks this process by activating retinoic acid signaling.

Summary: Maternal protein restriction increases fetal brain 5-HT and might contribute to changes in production and function of hypothalamic 5-HT_2C and 5-HT_2A receptors in the offspring later in life.

Summary: This paper sheds a new light on the role of the second heart field and neural crest cells in outflow tract formation in the mouse embryo. Depletion of the LPR2 results in a disturbed contribution pattern and subsequent common arterial trunk.

Summary: This paper increases the understanding of disease drivers and regulators in delayed-type hypersensitivity arthritis, a robust and reproducible arthritis model in C57BL/6 mice.

Summary: In this article, the authors demonstrate that a peptide with actions mainly in the cardiovascular system prevents the skeletal muscle damage induced by disuse.

Summary: This study describes a new iPSC model of X-linked dystonia-parkinsonism (XDP), which was initially validated by demonstrating a similar transcriptional defect as has been previously reported in XDP brain tissue.

Summary: We have created two transgenic models expressing ubiquitous GFP in WKY and SHR rat lines to support in vivo and ex vivo studies. We show their characterisation and discuss their potential use for translational research.

Summary: A refined platform approach for endotoxin-induced uveitis, using multimodal ex vivo and in vivo assessment, to improve quantification and phenotyping in this ocular model of compartmentalised tissue inflammation.