Issues

Summary: DMM announces changes to its Senior Editor team and thanks its many reviewers.

Summary: Raising standards for carrying out and reporting mouse model studies will improve reproducibility and relevance to human disease research.

Summary: This article reviews the similarities between embryogenesis and cancer progression and discusses how the concepts and techniques of developmental biology are being applied to provide insight into all aspects of tumorigenesis.

Summary: The short-lived African turquoise killifish is an emerging experimental vertebrate model organism, ideal for studies aimed at discovering the basic mechanisms underlying vertebrate ageing and adult phenotypes.

Editors' choice: This study demonstrates the utility of a transgenic mouse model of breast cancer to define mechanisms of resistance to a pan-HER family inhibitor and identifies a link with EMT.

Summary: CXCR4-expressing human tumor cells respond to zebrafish cognate ligands and initiate metastatic events in a zebrafish xenograft model. The CXCR4 antagonist IT1t has promising tumor inhibitory effects.

Summary: Live imaging in the medaka, a popular fish model for human bone research, shows that osteoclast inhibition by bisphosphonates triggers an efficient repair of bone defects by redistributed osteoblasts.

Summary: Structural and compositional basement membrane defects and ER stress due to Col4a1 mutations cause glomerular and tubular kidney disease, and indicate cell-type-specific disease mechanisms for collagen diseases.

Summary: Hyperglycemia inhibited Pax6 via oxidative stress and impaired eye development in the chick embryo, a new gestational diabetes mellitus model.

Summary: We developed a gnotobiotic threespine stickleback system to identify the cellular and genetic bases for variation in inflammatory responses to microbiota.

Summary: This zebrafish xenotransplant model of glioblastoma enables in vivo imaging of tumor cells and rapid screening for anti-glioma agents. It provides standardization of a model that is easily replicated across laboratories.

Summary: An active tamoxifen derivative can be used for the in vivo induction of recombination in situ in mice by CreERT2. We show how this method can be used to generate brain tumours through recombination of tumour suppressor genes in the subventricular zone.

Summary: Rabbit fetuses with induced diaphragmatic hernia and treated with prenatal tracheal occlusion have a similar pulmonary transcriptome as unaffected controls. This study describes a valuable database of gene expressions in this model.