Issues
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Cover image
Cover Image
Cover: The image shows the binding modes of a calixpyrrole derivative (C4PY) to the G-protein estrogen receptor (GPER), whose surface is coloured according to its electrostatic potential (blue positive and red negative). The macrocycle rings of C4PY interact with the receptor binding cleft through a hydrogen bond with the residue Glu115 and different hydrophobic contacts with residues Leu119, Thr201, Phe206, Phe208, Arg299, His302, Pro303 and His307, thus involving amino acids belonging to the extracellular loop 2 and the transmembrane helices II and VII as ascertained by computational analysis. See article by Lappano et al. on page 1237.
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SUBJECT COLLECTION: MODEL SYSTEMS IN DRUG DISCOVERY
EDITORIALS
From bench to patient: model systems in drug discovery
Drug Discovery Collection: This Editorial introduces the new DMM Special Collection entitled ‘From bench to patient: model systems in drug discovery’, providing a summary of its contents and highlighting the impact of multiple model systems in moving new discoveries from bench to patient.
Improving translational studies: lessons from rare neuromuscular diseases
Drug Discovery Collection: This Editorial reviews problems and some solutions to the translational use of animal models in the rare neuromuscular diseases context. This can serve as a model for other disease fields.
A MODEL FOR LIFE
REVIEW
GEMMs as preclinical models for testing pancreatic cancer therapies
Drug Discovery Collection: This Review discusses GEMMs of human pancreatic cancer, particularly focusing on the KPC model, its use in preclinical research, advantages and disadvantages, and its potential for predicting clinical outcomes.
RESEARCH ARTICLES
A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics
Editor's choice - Drug Discovery Collection: The study describes a rapid in vivo screen for novel strategies to treat pancreatic ductal adenocarcinoma (PDA).
Treatment with a novel oleic-acid–dihydroxyamphetamine conjugation ameliorates non-alcoholic fatty liver disease in obese Zucker rats
Drug Discovery Collection: OLHHA is a safe drug with hepatoprotective and anti-steatotic effects on non-alcoholic fatty liver disease in obese rats.
Precision-cut kidney slices (PCKS) to study development of renal fibrosis and efficacy of drug targeting ex vivo
Drug Discovery Collection: TGFβ induces renal fibrosis in ex vivo cultured precision-cut kidney slices, which can be attenuated by IFNγ.
A calixpyrrole derivative acts as an antagonist to GPER, a G-protein coupled receptor: mechanisms and models
Drug Discovery Collection: This paper highlights mechanisms through which a calixpyrrole derivative acts as a newly identified selective antagonist of GPER in different model systems.
Glycolytic inhibitor 2-deoxyglucose simultaneously targets cancer and endothelial cells to suppress neuroblastoma growth in mice
Drug Discovery Collection: Neuroblastomas are sensitive to treatment with the glycolytic inhibitor 2-deoxyglucose, which can simultaneously target cancer and endothelial cells to suppress tumor growth.
RESOURCE ARTICLE
From drug response profiling to target addiction scoring in cancer cell models
Drug Discovery Collection: The authors take a pan-cancer approach that provides functional insights into molecular vulnerabilities across various cancer subtypes and patient-specific target addiction patterns that could lead to actionable treatment strategies.
RESEARCH ARTICLES
Impaired APP activity and altered Tau splicing in embryonic stem cell-derived astrocytes obtained from an APPsw transgenic minipig
Summary: Insight into astrocyte and radial glia pathology in an in vitro culture system derived from the APPsw pig.
Interplay among Drosophila transcription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy
Summary: This study provides genetic evidence that malignancy driven by oncogenic Ras and loss of polarity requires transcription factors of three distinct protein families, acting in synergy downstream of JNK signaling.
OTX2 exhibits cell-context-dependent effects on cellular and molecular properties of human embryonic neural precursors and medulloblastoma cells
Summary: Human embryonic stem cell neural derivatives can be used to model the molecular and cellular properties of medulloblastoma.
Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy
Summary: Activation of the HSP70-TLR4 axis by albumin in the tubular cell induces tubular inflammation and injury.
Transient alteration of the vestibular calyceal junction and synapse in response to chronic ototoxic insult in rats
Summary: New forms of damage and repair have been identified in the vestibular sensory epithelium using a rat model of chronic ototoxicity and recovery that causes reversible vestibular dysfunction.
CORRECTION
Sex matters in preclinical research
DMM calls for improved inclusion, analysis and reporting of sex as a biological variable in preclinical animal modelling research. Read the full Editorial by Monica J. Justice.
Subject collection: Building advocacy into research
DMM’s new series - Building advocacy into research - features interviews, ‘The Patient’s Voice’, with patients and advocates for a range of disease types, with the aim of supporting the highest quality research for the benefit of all patients affected by disease.
Travelling Fellowships for early-career researchers
DMM and its sister journals offer Travelling Fellowships of up to £3,000 to graduate students and post-doctoral researchers wishing to make collaborative visits to other laboratories. Find out more about our Travelling Fellowships and read stories from previous grant recipients.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
The Forest of Biologists
Our Publisher Claire Moulton recently visited the two Woodland Trust UK sites where we are planting new native trees for published Research and Review papers and protecting ancient woodland on behalf of our peer reviewers.
