Issues
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Cover: Courtesy of Christopher M. Dooley, Wellcome Trust Sanger Institute. - PDF Icon PDF LinkTable of contents
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EDITORIAL
A MODEL FOR LIFE
From fish tank to bedside in cancer therapy: an interview with Leonard Zon
Leonard Zon, who is based at Harvard Medical School, is internationally recognized for his pioneering work in hematology and stem cell biology. His lab uses zebrafish as a model to understand blood cell development and, in recent years, has made inspiring breakthroughs in the treatment of blood diseases and cancer, helping to establish zebrafish as a powerful model for translational research. In this interview, Leonard speaks to Disease Models & Mechanisms Editor-in-Chief, Ross Cagan, about the evolution of his career from developmental biologist to physician-scientist and the stories behind some of his major research accomplishments. He also discusses challenges and opportunities in zebrafish research and provides advice on translating basic research findings to the clinic.
AT A GLANCE
REVIEWS
RESEARCH ARTICLES
Intravital correlated microscopy reveals differential macrophage and microglial dynamics during resolution of neuroinflammation
RESOURCE ARTICLES
DMM Journal Meeting 2024: Pre-clinical Modelling of Human Genetic Disease and Therapy
Registration is now open for our 2024 Journal Meeting. Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new hope for gene therapies. At this Meeting, we will present the very latest advances in modelling human genetic disease.
A new call for papers is underway
Showcase your latest research in our upcoming special issue Translating Multiscale Research in Rare Disease, coordinated by DMM Editors Monica Justice, Karen Liu and Monkol Lek, and Guest Editor Kate Rauen. The deadline for submitting articles to the special issue is Monday 6 November 2023.
Moving towards heart success – Disease Models & Mechanisms Special Issue
DMM's most recent special issue compiles articles that aim to move heart failure to heart success by fundamentally addressing the roots of failure to identify curative strategies.
Crossroads in Virology
Our October Editorial written by Sumana Sanyal emphasises the urgency of a concerted effort in understanding virus–host interactions to inform the development of therapeutics and vaccines, helping to predict disease outcomes. Read the full Editorial here.
NOTCH signalling – a core regulator of bile duct disease?
In this Review, Anabel Martinez Lyons and Luke Boulter explore the concepts of NOTCH signalling reactivation in the biliary epithelium and how it is a reiterative and essential response to bile duct damage. Read the full Review Article here.
