Issues
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Cover Image
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Cover: Consistent left-right patterning of the heart and viscera is a crucial part of embryogenesis. The cover shows a ventral view of the Xenopus tadpole, with pseudocolouring that reveals the asymmetric positions and morphogenesis of the gut (yellow), heart (pink) and gall bladder (green); the embryo on the left is normal, whereas its mirror image on the right depicts one with situs inversus. Xenopus is an important model organism for the study of developmental asymmetries because work in this system has most clearly revealed the molecular pathways that align the left-right axis shortly after fertilisation. Because errors of laterality form a common class of birth defects, understanding the mechanisms and timing at which left-right asymmetry is initiated is essential for human health. See article by Vandenberg et al. on page 261.Close Modal - PDF Icon PDF LinkTable of contents
In This Issue
Journal Club
Modelling how initiating and transforming oncogenes cooperate to produce a leukaemic cell state
Summary of and comment on a recent Cell Stem Cell paper entitled ‘Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells’ (Ashton et al., 2012).
A Model For Life
Driving change in tuberculosis research: an interview with Anne O’Garra
Anne O’Garra is Head of the Division of Immunoregulation at the MRC National Institute for Medical Research (NIMR) in Mill Hill, London. In this interview, she recounts the excitement of her early career discoveries on cytokines and T-cell differentiation, and discusses progress on tuberculosis research by her group and multiple collaborators.
Clinical Puzzle
Reviews
Research Articles
A zebrafish model of congenital disorders of glycosylation with phosphomannose isomerase deficiency reveals an early opportunity for corrective mannose supplementation
Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rγnull mice engrafted with human peripheral blood mononuclear cells
Research Report
Resource Article
Special Issue: The RAS Pathway
Our latest special issue is now complete. It showcases RAS-driven mechanisms of disease progression, and highlights approaches to treat and modify the disease course in model systems.
Call for papers: Moving Heart Failure to Heart Success
Disease Models & Mechanisms is pleased to welcome submissions for consideration for an upcoming special issue, Moving Heart Failure to Heart Success: Mechanisms, Regeneration & Therapy. Submission deadline: 4 July 2022.
Propose a new Workshop
Our Workshops bring together leading experts and early-career researchers from a range of scientific backgrounds. Applications are now open to propose Workshops for 2024, one of which will be held in a Global South country. .
A focus on Drosophila
In a series of front section articles, DMM is highlighting the versatility, breadth, and scope of Drosophila research in human disease modelling and translational medicine.
Apply for a DMM Conference Travel Grant
Aimed at early-career researchers wanting to attend in-person and virtual meetings, the next application deadline for a DMM Conference Travel Grant is 6 June 2022. Find out more and hear from past recipients about their experience of the grant.
