Issues
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Cover image
Cover Image
Mice with a conditional deletion of the Pten gene in neurons recapitulate many features of cortical dysplasia, a common cause of childhood epilepsy. These include spontaneous seizures, cell hypertrophy and elevated activity of the PI3K-Akt-mTOR signaling pathway. In the foreground are EEG traces showing different types of epileptiform activity in the mutant mice (bottom four traces) compared with wild-type mice (top trace). In the background is a section of the Pten mutant mouse cerebral cortex labeled with antibodies against Pten (green) and phospho-S6 (red). This image reveals the excessive activation of the PI3K-Akt-mTOR pathway in enlarged, Pten-negative neurons. See research article by Ljungberg et al. on page 389. - PDF Icon PDF LinkTable of contents
IN THIS ISSUE
RESEARCH HIGHLIGHT
JOURNAL CLUB
EDITORIAL
COMMUNITY NEWS
A MODEL FOR LIFE
Anti-angiogenic drugs to treat human disease: an interview with Napoleone Ferrara
Napoleone Ferrara identified vascular endothelial growth factor (VEGF) as a major regulator of blood vessel development. The antibodies that he and his colleagues created to block VEGF action also block cancer growth. Here, he discusses the work that led to the development of the anti-cancer drug Avastin (bevacizumab), and discusses the role of basic science in clinical medicine.
FEATURE
Researchers focus on inflammation at the Istituto Clinico Humanitas
With international recognition as a premier medical institute, the Istituto Clinico Humanitas pulls disease questions from their patients in the clinic into their preclinical work in the lab investigates.
CLINICAL PUZZLE
PRIMER
COMMENTARY
PERSPECTIVE
RESEARCH ARTICLE
An ENU-induced mutation in mouse glycyl-tRNA synthetase (GARS) causes peripheral sensory and motor phenotypes creating a model of Charcot-Marie-Tooth type 2D peripheral neuropathy
RESEARCH REPORT
Sex matters in preclinical research
DMM calls for improved inclusion, analysis and reporting of sex as a biological variable in preclinical animal modelling research. Read the full Editorial by Monica J. Justice.
Subject collection: Building advocacy into research
DMM’s new series - Building advocacy into research - features interviews, ‘The Patient’s Voice’, with patients and advocates for a range of disease types, with the aim of supporting the highest quality research for the benefit of all patients affected by disease.
Travelling Fellowships for early-career researchers
DMM and its sister journals offer Travelling Fellowships of up to £3,000 to graduate students and post-doctoral researchers wishing to make collaborative visits to other laboratories. Find out more about our Travelling Fellowships and read stories from previous grant recipients.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
The Forest of Biologists
Our Publisher Claire Moulton recently visited the two Woodland Trust UK sites where we are planting new native trees for published Research and Review papers and protecting ancient woodland on behalf of our peer reviewers.
