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RESEARCH ARTICLES

Summary: Activation of R-spondin 1 signaling in the adrenal cortex leads to a sexually dimorphic phenotype in mice, causing hyperplasia in females and immune cell recruitment in males.

Summary: Simultaneous inhibition of gba1 and smpd1 gene function (both implicated in Parkinson's disease) unexpectedly rescues neuronal gene expression and mitochondrial defects, and extends the lifespan of gba1 mutant zebrafish.

Summary: Vemurafenib partially improves muscle histopathology by restoring the TGF-β/SMAD3 and mTORC1/p70S6K signaling pathways but does not improve muscle function in a mouse model of LAMA2-related-congenital muscular dystrophy.

Summary: Surgical rescue of Ednrb−/− rats, a model for Hirschsprung disease, required dietary intervention for survival and showed reduced colon diameter in the aganglionic region, overall normal histology and changes in innervation.

RESOURCE ARTICLES

Summary: Development of an automated image analysis workflow to enable fast and reliant immune cell counting in Shigella-infected zebrafish larvae, and to reveal the in vivo impact of antibiotics on Shigella–neutrophil interactions.

Summary: A new zebrafish transgenic line that labels the expression of the gene arg2 can be used to visualise immune cell polarisation and investigate the mechanisms of innate immunity during infections.

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