Issues
-
Cover image
Cover Image
Cover: Confocal microscopy image of a glomerulus 8 h after intravenous administration of doxorubicin, showing binding of plasminogen (red) to the glomerular endothelium (blue) but not the podocytes ( green; DAPI, white). This binding is a prerequisite for the induction of doxorubicin-induced nephropathy in 129S1/SvImJ mice, representing a model for the investigation of nephrotic syndrome and chronic kidney disease. See also the article by Bohnert et al. (dmm049038), which describes a single-nucleotide polymorphism (SNP) in the Prkdc gene, and plasminogen binding to glomeruli as prerequisites to induce nephropathy in this model. See article by Bohnert et al. (dmm049038). Cover image is licensed under a Creative Commons Attribution 4.0 International license.
- PDF Icon PDF LinkTable of contents
- PDF Icon PDF LinkIssue info
EDITOR'S CHOICE
EDITORIAL
A MODEL FOR LIFE
AT A GLANCE
The developmental origins of Notch-driven intrahepatic bile duct disorders
Summary: In this At a Glance article and poster, we explore the mechanisms of Notch signaling and discuss how the field has concluded that Notch signaling is a central determinant in bile duct formation and growth.
REVIEW
Engineering chromosome rearrangements in cancer
Summary: Chromosome rearrangements can be potent cancer drivers and effective therapeutic targets. Here, we review how genome-editing technologies can be exploited to engineer and study complex structural variants, and identify new treatment options.
RESEARCH ARTICLES
Transforming growth factor β3 deficiency promotes defective lipid metabolism and fibrosis in murine kidney
Summary: Our study describes the renal abnormalities of heterozygous Tgfb3-targeted mice and suggests that TGFβ3 is renoprotective and may counteract the activity of TGFβ1.
A mouse model of brittle cornea syndrome caused by mutation in Zfp469
Summary: A mouse model of brittle cornea syndrome was created to elucidate molecular mechanisms underlying the pathology of this rare connective tissue disorder in which extremely thin corneas rupture, causing irreversible blindness.
Emotional behavior and brain anatomy of the mdx52 mouse model of Duchenne muscular dystrophy
Summary: The mdx52 mouse model of Duchenne muscular dystrophy lacks brain Dp427 and Dp140 dystrophins, and exhibits emotional, behavioral and learning phenotypes that are relevant for use in preclinical studies of the disorder.
dCubilin- or dAMN-mediated protein reabsorption in Drosophila nephrocytes modulates longevity
Summary: dCubilin- or dAMN-mediated protein reabsorption in nephrocytes from hemolymph modulates Drosophila lifespan through regulating proteostasis and aging in muscle and brain tissues via the tele-proteostasis mechanism.
Impaired aerobic capacity and premature fatigue preceding muscle weakness in the skeletal muscle Tfam-knockout mouse model
Summary: A time-course study of mitochondrial and muscular dysfunctions in a mouse model of mitochondrial myopathy reveals that decreased resistance to fatigue together with decreased oxidative capacities arise ahead of muscle weakness.
Essential role of DNA-PKcs and plasminogen for the development of doxorubicin-induced glomerular injury in mice
Summary: Susceptibility to doxorubicin-induced nephropathy in 129S1/SvImJ mice is determined by a hierarchical two-hit process requiring the C6418T single-nucleotide polymorphism in the Prkdc gene and subsequent glomerular binding of plasminogen.
Mycobacteriophage–antibiotic therapy promotes enhanced clearance of drug-resistant Mycobacterium abscessus
Summary: A zebrafish model of infection was developed to evaluate the in vivo cooperative activity of specific phages and antibiotics for the treatment of Mycobacterium abscessus infection.
Activation of innate immunity during development induces unresolved dysbiotic inflammatory gut and shortens lifespan
Editor's choice: This study took advantage of Drosophila genetics to demonstrate how mild inflammation in early life can be a risk factor of life-long health via alteration of the gut microbiota.
FIRST PERSON
Sex matters in preclinical research
DMM calls for improved inclusion, analysis and reporting of sex as a biological variable in preclinical animal modelling research. Read the full Editorial by Monica J. Justice.
Subject collection: Building advocacy into research
DMM’s new series - Building advocacy into research - features interviews, ‘The Patient’s Voice’, with patients and advocates for a range of disease types, with the aim of supporting the highest quality research for the benefit of all patients affected by disease.
Travelling Fellowships for early-career researchers
DMM and its sister journals offer Travelling Fellowships of up to £3,000 to graduate students and post-doctoral researchers wishing to make collaborative visits to other laboratories. Find out more about our Travelling Fellowships and read stories from previous grant recipients.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
The Forest of Biologists
Our Publisher Claire Moulton recently visited the two Woodland Trust UK sites where we are planting new native trees for published Research and Review papers and protecting ancient woodland on behalf of our peer reviewers.