Issues
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Cover image
Cover Image
Cover: Human colon epithelium, stained with phospho-SQSTM1 (p62; green) and DAPI (blue) to indicate correlation of SQSTM1 accumulation with autophagy status in vivo, as related to the Crohn's disease-specific ATG16L1 T300A single-nucleotide polymorphism. See article by Prins et al. (dmm047233). Cover image is licensed under a Creative Commons Attribution 4.0 International license.
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EDITORIAL
REVIEWS
The liver metastatic niche: modelling the extracellular matrix in metastasis
Summary: Extracellular matrix dynamics are emerging as a key feature of metastasis. We discuss the changes in matrix composition of the liver metastatic niche, how these impact disease progression, and the approaches to study this topic.
miRNA interplay: mechanisms and consequences in cancer
Summary: MicroRNAs are capable of self-targeting, which has implications on their biogenesis, their canonical role in gene regulation and on cancer development.
RESEARCH ARTICLES
Automated in vivo drug screen in zebrafish identifies synapse-stabilising drugs with relevance to spinal muscular atrophy
Summary: We report an automated and high-throughput screening platform to identify compounds relevant to motor neuron disease using younger, less-pigmented zebrafish embryos.
Identification of fibronectin 1 as a candidate genetic modifier in a Col4a1 mutant mouse model of Gould syndrome
Summary: We performed a genetic screen in Col4a1 mutant mice to elucidate the mechanisms contributing to Gould syndrome. Our results implicate FN1 as a genetic modifier of some, but not all, aspects of Gould syndrome.
An Fgfr3-activating mutation in immature murine osteoblasts affects the appendicular and craniofacial skeleton
Editor's choice: In a mouse model of achondroplasia, targeting an Fgfr3-activating mutation to immature osteoblasts led to osteopenia and induced craniofacial membranous bone defects.
Thiopurines correct the effects of autophagy impairment on intestinal healing – a potential role for ARHGAP18/RhoA
Summary: Analyses of HT29 cells after ATG16L1 knockdown reveal a novel biological mechanism for the association between the autophagy pathway and Crohn's disease, and could aid personalized medicine strategies in Crohn's disease therapy.
Joint development recovery on resumption of embryonic movement following paralysis
Summary: Embryonic movement post paralysis can partially recover specific aspects of joint development, which could inform therapeutic approaches to ameliorate the effects of restricted fetal movement in utero.
Sex differences in insulin resistance, but not peripheral neuropathy, in a diet-induced prediabetes mouse model
Summary: We established a prediabetic obese mouse model for studying sex dimorphism in peripheral neuropathy. Females retain early insulin sensitivity upon high-fat diet challenge, but develop the same degree of peripheral neuropathy as males.
RESOURCE ARTICLES
Metabolomics and lipidomics in Caenorhabditis elegans using a single-sample preparation
Summary: We describe an integrated metabolomics and lipidomics method for analyzing metabolites in C. elegans using a single-sample preparation, which provides a robust way of obtaining comprehensive, high-quality metabolic data from biological samples.
High-dimensional immunotyping of tumors grown in obese and non-obese mice
Summary: We used a mass cytometry analysis pipeline to immunophenotype tumor immune infiltrate from two pancreatic and three breast cancer murine models, identifying a link to obesity in the E0771 breast cancer model.
FIRST PERSON
Valuing peer review at Disease Models & Mechanisms
We would like to thank our peer reviewers who contributed their time and expertise in 2023. In her latest Editorial, Editor-in-Chief Liz Patton has outlined why we continue to value our peer reviewers dedication.
Subject collection: Building advocacy into research
DMM’s new series - Building advocacy into research - features interviews, ‘The Patient’s Voice’, with patients and advocates for a range of disease types, with the aim of supporting the highest quality research for the benefit of all patients affected by disease.
Travelling Fellowships for early-career researchers
DMM and its sister journals offer Travelling Fellowships of up to £3,000 to graduate students and post-doctoral researchers wishing to make collaborative visits to other laboratories. Find out more about our Travelling Fellowships and read stories from previous grant recipients.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
The Forest of Biologists
Our Publisher Claire Moulton recently visited the two Woodland Trust UK sites where we are planting new native trees for published Research and Review papers and protecting ancient woodland on behalf of our peer reviewers.