Issues
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Cover image
Cover Image
Cover: Expression of phenylalanyl tRNA synthetase subunit alpha (α-PheRS) twin-spot clones in the follicle cells of the fly ovary. Twin spot clones were generated with the wild-type α-PheRS clone (blue) expressing normal endogenous levels as internal control, and its twin clone expressing elevated levels of α-PheRS (orange). See article by Ho et al. (dmm048132). Cover image is licensed under a Creative Commons Attribution 4.0 International license.
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REVIEWS
Mending a broken heart: In vitro, in vivo and in silico models of congenital heart disease
Summary:In vitro, in vivo and in silico models of congenital heart disease provide important insights into the causes, evolution and pathological effects of congenital structural heart disease – a group of largely heterogenous disorders with substantial morbidity – and aid in designing effective therapies.
Modelling epilepsy in the mouse: challenges and solutions
Summary: This Review discusses the challenges of modelling epilepsy in mice, a condition in which the outward manifestation of the disorder appears only sporadically, and reviews possible solutions encompassing both genetic and induced models.
RESEARCH ARTICLES
Modulation of serotonin in the gut-liver neural axis ameliorates the fatty and fibrotic changes in non-alcoholic fatty liver
Summary: The gut-liver neural axis is involved in NAFLD progression and serotonin is the key factor in allowing this pathway to change the expression of tight junction molecules, microbiota diversity and short-chain fatty acids.
Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency
Summary: We established a RISPR/Cas9-mediated Uox gene-KO Wistar rat model of hyperuricemia, and show that autophagy and NLRP3-related inflammation are involved in uric acid nephropathy.
Transformed notochordal cells trigger chronic wounds in zebrafish, destabilizing the vertebral column and bone homeostasis
Summary: Analyses using a zebrafish line expressing RAS in the notochord, under the control of the kita promoter, revealed that transformed notochord cells alter the skeleton during life, causing a wound-like phenotype and activating chronic wound response.
Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation
Summary: Analyses of mice deficient in myeloid MCPIP1 reveal a function of myeloid MCPIP1 in the transition from autoinflammation to autoimmunity and a role for macrophage-dependent immune activation as a trigger of secondary autoimmunity.
High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition
Editor's choice: Experiments using overnourished sheep raised on a high-calorie liver-fattening diet, treated with and without thiamine, revealed that vitamin B1 protects against the development of fatty liver driven by overnutrition.
A translation-independent function of PheRS activates growth and proliferation in Drosophila
Summary: A moonlighting activity of the α-subunit of the Phenylalanyl tRNA synthetase in Drosophila promotes growth and proliferation through a novel mechanism that neither involves aminoacylation nor translation.
EZH2 is required for parathyroid and thymic development through differentiation of the third pharyngeal pouch endoderm
Summary: EZH2 in the pharyngeal apparatus is required in the endoderm for the development of the parathyroids and thymus, and positively regulates the expression of the Tbx1 gene.
NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CAH1047R homozygosity in pluripotent stem cells
Summary: Transcriptomic and proteomic analyses of iPSCs with allele-dose dependent expression of the PIK3CAH1047R oncogene confirm network rewiring in homozygous mutants, with self-sustained stemness likely driven by constitutive TGFβ/NODAL pathway activation.
RESOURCE ARTICLE
Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition
Summary: Combined application of polarisation-resolved second-harmonic generation microscopy and Raman spectroscopy identified unique, sexually dimorphic extracellular matrix signatures linking pathological matrix disorganisation with composition.
FIRST PERSON
DMM Journal Meeting 2023: Infectious Diseases Through an Evolutionary Lens

We are delighted to announce that our 2023 Journal Meeting ‘Infectious Diseases Through an Evolutionary Lens’ will be held from 17-19 October 2023 in London, UK. Find out more and register your interest here.
Louis Pasteur continues to shape the future of microbiology

To mark the 200th anniversary of the birth of Louis Pasteur, our Editorial Board member Serge Mostowy reflects on Pasteur’s legacy, and we interview Pascale Cossart, Head of the Bacteria-Cell Interactions Unit at Institut Pasteur.
Webinar: Increasing the visibility and impact of your research
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Would you like to increase the visibility and impact of your research and raise your profile internationally? If so, register for the very practical webinar we are running in association with HUBS on 23 February 2023.
Live imaging adult disease processes

The optical transparency of zebrafish larvae facilitates live imaging, but this transparency is not maintained into adulthood. To address this, Pui-Ying Lam’s Resource Article demonstrates the feasibility of imaging adult Danionella cerebrum. This article has been highlighted as our Editor’s Choice by Kristen Kwan.
Apply for a DMM Conference Travel Grant

Aimed at early-career researchers wanting to attend in-person and virtual meetings, the next application deadline for a DMM Conference Travel Grant is 3 March 2023. Find out more and hear from past recipients about their experience of the grant.