Issues
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Cover image
Cover Image
Cover: Confocal microscopy image showing immunoreactive glial fibrillar acidic protein (GFAP; red) and amyloid precursor protein (APP; green) in rat primary control cultured astrocytes. See article by Wu et al. (dmm048929), which describes that exosomes derived from cholesterol-accumulated astrocytes can play an important role in trafficking APP and its cleaved product β-amyloid peptide, which can subsequently be taken up and influence the viability of neurons. Cover image is licensed under a Creative Commons Attribution 4.0 International license.
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EDITOR'S CHOICE
EDITORIAL
Hot to touch: the story of the 2021 Nobel Prize in Physiology or Medicine
Summary: This year’s Nobel Prize in Physiology or Medicine celebrates how even the most fundamental of science can lead to broad applications for improving health and wellbeing.
REVIEWS
Infant leukaemia – faithful models, cell of origin and the niche
Summary: In this Review we discuss how MLL gene rearrangements cooperate with transient facilitators presented by the foetal environment to initiate the development of infant leukaemia, and evaluate current leukaemia models.
Genetically altered animal models for ATP1A3-related disorders
Summary: This Review provides an overview of the animal models used to study the spectrum of ATP1A3-related disorders and discusses their contribution towards better understanding of pathological mechanisms and novel therapeutics.
RESEARCH ARTICLES
Implications of exosomes derived from cholesterol-accumulated astrocytes in Alzheimer's disease pathology
Summary: Cholesterol accumulation within astrocytes can influence secretion of exosomes containing β-amyloid-related peptides. Uptake of these exosomes can induce neurotoxicity, suggesting their potential implication in Alzheimer's disease pathogenesis.
Rapamycin modulates pulmonary pathology in a murine model of Mycobacterium tuberculosis infection
Summary: Rapamycin, an mTOR inhibitor, with or without moxifloxacin, reduces lung inflammation and the number and size of caseating necrotic granulomas in Mycobacterium tuberculosis-infected C3HeB/FeJ mice.
Morc2a p.S87L mutant mice develop peripheral and central neuropathies associated with neuronal DNA damage and apoptosis
Summary: We present a new mouse model of Charcot-Marie-Tooth disease type 2 Z and developmental delay, impaired growth, dysmorphic facies and axonal neuropathy syndrome with a Morc2a p.S87L mutation, exhibiting peripheral and central neuronal apoptosis.
Development and characterization of an animal model of Japanese encephalitis virus infection in adolescent C57BL/6 mouse
Summary: We generated a mouse-adapted Japanese encephalitis virus (JEV) isolate to develop and characterize a mouse model of JEV infection, which could be a useful tool to screen antivirals and study JEV pathogenesis.
Integrative transcriptomic profiling of a mouse model of hypertension-accelerated diabetic kidney disease
Summary: Combining single-nucleus RNAseq with glomerular and cortical gene expression profiling can link kidney transcriptome signatures to specific cell types in an advanced mouse model of hypertension-accelerated diabetic kidney disease.
Propensity to endoplasmic reticulum stress in deer mouse fibroblasts predicts skin inflammation and body weight gain
Summary: Using outbred deer mice, we show that the unfolded protein response operates as a modifier of propensity for body weight gain in a manner involving the regulation of an inflammatory response by skin fibroblasts.
Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes
Editor's choice: Comprehensive phenotyping shows that Dp1Tyb mice, a model of Down syndrome (DS), have a broad range of DS-related phenotypes and can be used to investigate causative genes and their pathological mechanisms.
RESOURCE ARTICLE
Flow cytometry allows rapid detection of protein aggregates in cellular and zebrafish models of spinocerebellar ataxia 3
Summary: Description of a flow cytometric methodology for the rapid detection and quantification of detergent-insoluble protein aggregates within cultured cells and transgenic zebrafish modelling spinocerebellar ataxia 3.
FIRST PERSON
Sex matters in preclinical research
DMM calls for improved inclusion, analysis and reporting of sex as a biological variable in preclinical animal modelling research. Read the full Editorial by Monica J. Justice.
Subject collection: Building advocacy into research
DMM’s new series - Building advocacy into research - features interviews, ‘The Patient’s Voice’, with patients and advocates for a range of disease types, with the aim of supporting the highest quality research for the benefit of all patients affected by disease.
Travelling Fellowships for early-career researchers
DMM and its sister journals offer Travelling Fellowships of up to £3,000 to graduate students and post-doctoral researchers wishing to make collaborative visits to other laboratories. Find out more about our Travelling Fellowships and read stories from previous grant recipients.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
The Forest of Biologists
Our Publisher Claire Moulton recently visited the two Woodland Trust UK sites where we are planting new native trees for published Research and Review papers and protecting ancient woodland on behalf of our peer reviewers.