Issues
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Cover image
Cover Image
Cover: Photoreceptors in Drosophila adult compound eyes. The number of rhabdomeres (marked with phalloidin staining; green) within photoreceptors (outlined with Na+/K+-ATPase staining; magenta) is decreased in dDBT-deficient Drosophila compared to that in wild type, indicating that loss of dDBT activity results in neuronal damage. See article by Tsai et al. (dmm044750). Cover image is licensed under a Creative Commons Attribution 4.0 International license.
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EDITORIAL
FIRST PERSON
REVIEWS
Sex-dependent effect of APOE on Alzheimer's disease and other age-related neurodegenerative disorders
Summary: The APOE ε4 allele and female sex are among the strongest risk factors for late-onset Alzheimer's disease. We explore how the interplay between these factors affects risk for this and other age-related neurodegenerative diseases.
Integrating fish models in tuberculosis vaccine development
Summary: In this Review, we discuss how zebrafish (Danio rerio) and other fish models can complement the more traditional mammalian models in the development of novel vaccines against tuberculosis.
RESEARCH ARTICLES
Loss of the Drosophila branched-chain α-ketoacid dehydrogenase complex results in neuronal dysfunction
Summary: Loss of BCKDH activity in Drosophila recapitulates the neurological symptoms of patients with maple syrup urine disease. Metformin administration was found to alleviate developmental defects and aberrant behavior in the BCKDH mutant.
A regulated NMD mouse model supports NMD inhibition as a viable therapeutic option to treat genetic diseases
Summary: Nonsense-mediated mRNA decay can be inhibited after completion of mammalian prenatal development without adverse effects in non-neurological, somatic tissues, indicating that such inhibition might be a viable therapeutic strategy.
Maltodextrin-induced intestinal injury in a neonatal mouse model
Summary: Using maltodextrin-dominant human infant formula feeding in combination with hypoxia, we developed a highly reproducible model of small intestinal injury in the neonatal mouse.
Generation and characterization of an Il2rg knockout Syrian hamster model for XSCID and HAdV-C6 infection in immunocompromised patients
Summary: Syrian hamsters are an important rodent species for studying multiple human diseases. We describe the generation and characterization of a hamster strain that is defective in the XCSID-associated IL2RG gene.
suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types
Summary: In p53- and nf1-deficient zebrafish, onset of MPNSTs, as well as diverse other tumors, is accelerated by loss of the suz12 tumor suppressor, accompanied by global reduction in H3K27me3 marks and increased Ras-Mapk signaling.
Nrf2/HO-1 mediates the neuroprotective effects of pramipexole by attenuating oxidative damage and mitochondrial perturbation after traumatic brain injury in rats
Editor's choice: We administered pramipexole (PPX) to rats after a traumatic brain injury (TBI) and evaluated various parameters, which indicate that the neuroprotective effects of PPX are mediated by activation of the Nrf2/HO-1 signaling pathway following TBI.
The transcription factor Maz is essential for normal eye development
Summary: Our study has uncovered Maz as an important regulator of eye development in humans and mice, striving to elucidate the role of this gene in eye abnormalities associated with the human ch16p11.2 microdeletions and microduplications.
Systemic and heart autonomous effects of sphingosine Δ4 desaturase deficiency in lipotoxic cardiac pathophysiology
Summary: Systemic versus heart autonomous functions of sphingosine Δ4 desaturase differentially regulate cardiac structure and function in a tissue-specific manner in Drosophila, where organ interplay mimics that observed in mammalian systems.
Valuing peer review at Disease Models & Mechanisms
We would like to thank our peer reviewers who contributed their time and expertise in 2023. In her latest Editorial, Editor-in-Chief Liz Patton has outlined why we continue to value our peer reviewers dedication.
Subject collection: Building advocacy into research
DMM’s new series - Building advocacy into research - features interviews, ‘The Patient’s Voice’, with patients and advocates for a range of disease types, with the aim of supporting the highest quality research for the benefit of all patients affected by disease.
Travelling Fellowships for early-career researchers
DMM and its sister journals offer Travelling Fellowships of up to £3,000 to graduate students and post-doctoral researchers wishing to make collaborative visits to other laboratories. Find out more about our Travelling Fellowships and read stories from previous grant recipients.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
The Forest of Biologists
Our Publisher Claire Moulton recently visited the two Woodland Trust UK sites where we are planting new native trees for published Research and Review papers and protecting ancient woodland on behalf of our peer reviewers.