Issues
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Cover image
Cover Image
Cover: Wild-type Drosophila eye imaginal epithelia showing Stat-GFP (red) and Actin (green) expression. See article by Harsh et al. (dmm040816). The authors observe that Drosophila eye imaginal discs carrying overexpression of Zika virus NS4A are smaller in size and show reduced expression of Stat-GFP, the in vivo reporter of JAK/STAT signaling, compared to wild type, while the overall architecture of the tissue (as shown by Actin) is unaffected. Stat-GFP expression in the antenna part of the eye tissue remains unaffected for wild-type Drosophila and those carrying Zika virus NS4A overexpression. Cover image is licensed under a Creative Commons Attribution 4.0 International license.
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Casting a wide net: use of diverse model organisms to advance toxicology
Summary: This Editorial highlights the value of utilizing evolutionarily diverse model systems, including zebrafish, in basic toxicology research to investigate mechanisms of chemical-induced disease.
Membrane trafficking in health and disease
Summary: This At a Glance article and poster summarise the major intracellular membrane trafficking pathways and associated molecular machineries, and describe how defects in these give rise to disease in humans.
Zebrafish as a tool to study schizophrenia-associated copy number variants
Summary: Specific copy number variants significantly increase the risk of schizophrenia, although their mechanisms are incompletely understood. We review the zebrafish as a tool to begin to decipher the complex biology of these rare variants.
Zika virus non-structural protein NS4A restricts eye growth in Drosophila through regulation of JAK/STAT signaling
Summary: Our study provides evidence that Zika virus infection in Drosophila results in restricted growth of the developing eye and wing through regulation of JAK/STAT and Notch signaling, respectively.
DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of fibrolamellar carcinoma
Summary: Inflammation and Caspase-a activation occur early in a new zebrafish model for fibrolamellar carcinoma (FLC). Pharmacological inhibition of TNFα secretion and caspase-1 might be useful approaches to treat FLC patients.
Leptin and fractalkine: novel subcutaneous cytokines in burn injury
Summary: Burn injury is associated with increased levels of leptin and fractalkine in the skin. Signalling by these cytokines leads to macrophage accumulation and hypersensitivity to heat and mechanical stimuli.
Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis
Summary: This study describes a defatting cocktail that has been proven to function in three relevant steatotic human culture models without cytotoxicity, and which could be employed in the reduction of steatosis in donor livers during liver transplantation.
Familial hypercholesterolemia class II low-density lipoprotein receptor response to statin treatment
Editor's choice: Statin-induced upregulation of class II mutant LDLR does not cause acute endoplasmic reticulum (ER) stress and unfolded protein response induction, in spite of misfolded LDLR protein accumulation in the ER.
Gallbladder wall abnormality in biliary atresia of mouse Sox17+/− neonates and human infants
Summary: Metaplastic gland formation in gallbladder walls is seen in both human BA and the mouse Sox17-haploinsufficient BA model, indicating its contribution to the pathogenesis of human BA.
Sex matters in preclinical research
DMM calls for improved inclusion, analysis and reporting of sex as a biological variable in preclinical animal modelling research. Read the full Editorial by Monica J. Justice.
Subject collection: Building advocacy into research
DMM’s new series - Building advocacy into research - features interviews, ‘The Patient’s Voice’, with patients and advocates for a range of disease types, with the aim of supporting the highest quality research for the benefit of all patients affected by disease.
Travelling Fellowships for early-career researchers
DMM and its sister journals offer Travelling Fellowships of up to £3,000 to graduate students and post-doctoral researchers wishing to make collaborative visits to other laboratories. Find out more about our Travelling Fellowships and read stories from previous grant recipients.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
The Forest of Biologists
Our Publisher Claire Moulton recently visited the two Woodland Trust UK sites where we are planting new native trees for published Research and Review papers and protecting ancient woodland on behalf of our peer reviewers.