Cover: Movat pentachrome staining of the growth plate in undecalcified sections of tibia isolated from Gnptgko mice. Collagen is stained in yellow, proteoglycans in blue and the cytoplasm in red/pink. See article by Westermann et al. (dmm046425). Cover image is licensed under a Creative Commons Attribution 4.0 International license.
- PDF Icon PDF LinkTable of contents
- PDF Icon PDF LinkIssue info
Mouse models of myocardial infarction: comparing permanent ligation and ischaemia-reperfusion
Summary: Permanent ligation and ischaemia-reperfusion are common models for studying myocardial infarction. Here, we summarise the differences between them and outline the strengths of each in addressing distinct questions related to the human condition.
Akkermansia muciniphila promotes type H vessel formation and bone fracture healing by reducing gut permeability and inflammation
Summary: Akkermansia muciniphila reduces intestinal permeability and alleviates inflammation, inducing more PDGF-BB+ preosteoclasts and type H vessel formation in callus, thus promoting bone fracture healing.
Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney
Summary: Using a murine knockout model and analysis of human cells, we demonstrate a novel role for L-2-hydroxyglutarate dehydrogenase in the kidney as well as new insight into the mechanisms that regulate expression of this enzyme.
Restoration of motor learning in a mouse model of Rett syndrome following long-term treatment with a novel small-molecule activator of TrkB
Editor's choice: Long-term intermittent treatment with a newly developed partial agonist of the TrkB neurotrophin receptor reverses deficits in motor learning and respiration in a mouse model of Rett syndrome.
Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease
Summary: Using state-of-the-art in silico drug discovery and real-time live-cell imaging techniques, we identify clarithromycin as a drug with potential for repositioning for inflammatory bowel disease.
L-type voltage-gated calcium channel agonists mitigate hearing loss and modify ribbon synapse morphology in the zebrafish model of Usher syndrome type 1
Summary: We quantified behavioral and synaptic morphology differences between wild-type zebrafish larvae and the mariner (myo7aa−/−) mutant, finding that these differences can be modified by L-type voltage-gated calcium channel agonists.
Differential physiological roles for BIN1 isoforms in skeletal muscle development, function and regeneration
Summary: The BIN1 gene, mutated in centronuclear myopathies, expresses ubiquitous and muscle-specific isoforms. It is shown here that ubiquitous isoforms are necessary for muscle development, whereas muscle-specific isoforms fine-tune muscle regeneration.
Imbalanced cellular metabolism compromises cartilage homeostasis and joint function in a mouse model of mucolipidosis type III gamma
Summary: Analyses of Gnptg knockout mice indicate that functional joint abnormalities observed in mucolipidosis type III gamma patients are caused by imbalanced metabolism, leading to structural extracellular matrix changes in cartilage and tendons.
Duchenne muscular dystrophy (DMD) cardiomyocyte-secreted exosomes promote the pathogenesis of DMD-associated cardiomyopathy
Summary: This study examines the consequential effects of exposure to diseased exosomes in a cell model of Duchenne muscular dystrophy (DMD). The findings support a detrimental role for long-term DMD cardiac exosome exposure.
DMM Journal Meeting 2023: Infectious Diseases Through an Evolutionary Lens
We are delighted to announce that our 2023 Journal Meeting ‘Infectious Diseases Through an Evolutionary Lens’ will be held from 17-19 October 2023 in London, UK. Registration is open now.
The Forest of Biologists
We are excited to announce the launch of The Forest of Biologists, a new biodiversity initiative created with support from the Woodland Trust, aiming to counteract nature loss and safeguard some of the most critically endangered ecosystems for future generations. For every Research Article and Review article that is published in one of our five journals a native tree is planted in a forest in the UK. Take a look at our virtual forest online now.
Propose a new workshop for 2025
Do you have an idea for a Workshop? If so, click here. We are now accepting proposals for our 2025 Biologists Workshops programme. As the scientific organiser, your involvement will be focused on the science. We'll take care of all the logistics. In 2025 we'll continue our efforts to diversify our Workshop programme and will be reserving one of our Workshops for an application from a Global South (GS) country to host an event overseas.
New drugs to squash the spread of malaria
In this Research Article, the Baum lab identify a new class of antimalarials to block Plasmodium gamete formation. This article has been highlighted as our Editor’s Choice, and you can find out more in our interview with first author Sabrina Yahiya.
The shifting culture of the scientific workforce – a change for women and girls in science
February 11 marks The International Day of Women and Girls in Science (IDWGS) a celebration of the achievements of female scientists, and a call to action for a culture shift in science. Click here to read more about the day