Summary: Permanent ligation and ischaemia-reperfusion are common models for studying myocardial infarction. Here, we summarise the differences between them and outline the strengths of each in addressing distinct questions related to the human condition.
Akkermansia muciniphila promotes type H vessel formation and bone fracture healing by reducing gut permeability and inflammation
Summary: Akkermansia muciniphila reduces intestinal permeability and alleviates inflammation, inducing more PDGF-BB+ preosteoclasts and type H vessel formation in callus, thus promoting bone fracture healing.
Summary: Using a murine knockout model and analysis of human cells, we demonstrate a novel role for L-2-hydroxyglutarate dehydrogenase in the kidney as well as new insight into the mechanisms that regulate expression of this enzyme.
Restoration of motor learning in a mouse model of Rett syndrome following long-term treatment with a novel small-molecule activator of TrkB
Editor's choice: Long-term intermittent treatment with a newly developed partial agonist of the TrkB neurotrophin receptor reverses deficits in motor learning and respiration in a mouse model of Rett syndrome.
Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease
Summary: Using state-of-the-art in silico drug discovery and real-time live-cell imaging techniques, we identify clarithromycin as a drug with potential for repositioning for inflammatory bowel disease.
L-type voltage-gated calcium channel agonists mitigate hearing loss and modify ribbon synapse morphology in the zebrafish model of Usher syndrome type 1
Summary: We quantified behavioral and synaptic morphology differences between wild-type zebrafish larvae and the mariner (myo7aa−/−) mutant, finding that these differences can be modified by L-type voltage-gated calcium channel agonists.
Differential physiological roles for BIN1 isoforms in skeletal muscle development, function and regeneration
Summary: The BIN1 gene, mutated in centronuclear myopathies, expresses ubiquitous and muscle-specific isoforms. It is shown here that ubiquitous isoforms are necessary for muscle development, whereas muscle-specific isoforms fine-tune muscle regeneration.
Imbalanced cellular metabolism compromises cartilage homeostasis and joint function in a mouse model of mucolipidosis type III gamma
Summary: Analyses of Gnptg knockout mice indicate that functional joint abnormalities observed in mucolipidosis type III gamma patients are caused by imbalanced metabolism, leading to structural extracellular matrix changes in cartilage and tendons.
Duchenne muscular dystrophy (DMD) cardiomyocyte-secreted exosomes promote the pathogenesis of DMD-associated cardiomyopathy
Summary: This study examines the consequential effects of exposure to diseased exosomes in a cell model of Duchenne muscular dystrophy (DMD). The findings support a detrimental role for long-term DMD cardiac exosome exposure.