Issues
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Cover image
Cover Image
Cover: Drosophila third instar larval brain stained for aPKC (magenta), Elav (green, neurons), lamin (cyan, nuclear envelope), DNA was stained using DAPI (blue). The large magenta cells are neural stem cells, whereas the smaller green cells are differentiating neuronal lineages produced by an asymmetrically dividing stem cell. The image shows a partial z-projection. See article by Link et al. (dmm050297). Cover image is licensed under a Creative Commons Attribution 4.0 International license.
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EDITORIAL
Synergistic modelling of human disease
Summary: Increasingly complex research questions can be answered by using complimentary models of human disease. These systems can build a holistic representation of human disease and enable better translation to the clinic.
SPECIAL ARTICLE
Stem cell modeling of nervous system tumors
Summary: The application of human stem cell engineering to nervous system tumor modeling affords unique opportunities to study the cellular origins of tumors, examine cancer evolution and identify future therapeutic targets.
REVIEW
Shared features in ear and kidney development – implications for oto-renal syndromes
Summary: This Review summarizes the developmental pathways shared between inner ear and kidney formation and explores the mechanisms underlying oto-renal syndromes.
EDITOR'S CHOICE
RESEARCH ARTICLES
A common cellular response to broad splicing perturbations is characterized by metabolic transcript downregulation driven by the Mdm2–p53 axis
Summary: This work classifies how cells respond when their splicing is broadly disrupted, and explores the relevance of this response to cell-type-specific phenotypes.
Motor protein Kif6 regulates cilia motility and polarity in brain ependymal cells
Summary: Kif6 localizes to the axonemes of ependymal cells. In vitro analysis showed that Kif6 moves along microtubules and that, in mouse, its loss decreases cilia motility and cilia-driven flow, resulting in hydrocephalus.
Postnatal Zika virus infection leads to morphological and cellular alterations within the neurogenic niche
Summary: Following intracranial Zika virus infection in postnatal mice, the formation of the neurogenic niche within the dentate gyrus is affected and subgranular zone development is severely impaired.
PTCH1-mutant human cerebellar organoids exhibit altered neural development and recapitulate early medulloblastoma tumorigenesis
Summary: Cerebellar organoids recapitulate in vivo processes of regionalisation and SHH signalling, and offer new insight into early pathophysiological events of medulloblastoma tumorigenesis without the use of animal models.
RESOURCES & METHODS
A Zika virus protein expression screen in Drosophila to investigate targeted host pathways during development
Editor's choice: Expression of Zika virus proteins in Drosophila causes tissue-specific phenotypes, suggesting that they interact or inhibit specific host pathways during development to cause disease.
FIRST PERSON
PREPRINT HIGHLIGHTS
Valuing peer review at Disease Models & Mechanisms
We would like to thank our peer reviewers who contributed their time and expertise in 2023. In her latest Editorial, Editor-in-Chief Liz Patton has outlined why we continue to value our peer reviewers dedication.
Subject collection: Building advocacy into research
DMM’s new series - Building advocacy into research - features interviews, ‘The Patient’s Voice’, with patients and advocates for a range of disease types, with the aim of supporting the highest quality research for the benefit of all patients affected by disease.
Travelling Fellowships for early-career researchers
DMM and its sister journals offer Travelling Fellowships of up to £3,000 to graduate students and post-doctoral researchers wishing to make collaborative visits to other laboratories. Find out more about our Travelling Fellowships and read stories from previous grant recipients.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
The Forest of Biologists
Our Publisher Claire Moulton recently visited the two Woodland Trust UK sites where we are planting new native trees for published Research and Review papers and protecting ancient woodland on behalf of our peer reviewers.