The Mexican Biobank Project promotes genetic discovery, inclusive science and local capacity building
Summary: The Mexican Biobank captures biological factors at a nation-wide scale for the first time in Latin America. It is an inspiring example for leading such initiatives in the Global South.
Summary: We propose a standardization of criteria for drug screening and evaluation in zebrafish muscle disease models, with the goal of improving experimental rigor, reproducibility and translation.
Summary: We review how well-established and emerging Xiphophorus fishes and their interspecies hybrids can be used for studying human diseases, to highlight research opportunities enabled by these unique models.
Conditional in vivo deletion of LYN kinase has little effect on a BRCA1 loss-of-function-associated mammary tumour model
Summary: A Lyn conditional knockout mouse mammary tumour model shows little effect of knocking out LYN kinase in tumour cells but suggests a link between Lyn-expressing B cells and tumour growth inhibition.
eNOS plays essential roles in the developing heart and aorta linked to disruption of Notch signalling
Editor's choice: eNOS is essential during cardiogenesis and null mutants frequently die during embryogenesis or at birth. Cardiovascular defects in mildly affected adult survivors can be traced back to intrauterine life.
Summary: A murine model of post-traumatic stress disorder (PTSD)-induced bone loss serves as a valuable tool to investigate the underlying mechanisms of osteoporosis associated with PTSD.
RESOURCES & METHODS
Transcriptional profiling of zebrafish identifies host factors controlling susceptibility to Shigella flexneri
Summary: The transcriptional signature of zebrafish larvae infected with Shigella flexneri identifies acod1 and gpr84 as inducible factors that play a significant role in S. flexneri infection control.
Summary: We describe optimized protocols to generate organoid cultures from mouse esophageal and tongue epithelia and patient-derived esophageal samples. We also establish a co-culture model to assess CD8+ T cell-mediated tumor killing in patient samples.
Histological and functional characterization of 3D human skin models mimicking the inflammatory skin diseases psoriasis and atopic dermatitis
Summary: Distinct 3D human skin models with phenotypic features of the inflammatory skin diseases psoriasis and atopic dermatitis can be reliably used to test novel treatment strategies.