Sheng Zhang and colleagues report here the development of a Drosophila model for Huntington’s disease (HD), which recapitulates many of the symptoms seen in humans Deletion of the huntingtin gene in flies leads to progressively impaired mobility, an age-associated reduction in axonal termini complexity and a shortened life span. These neurological symptoms are exacerbated further by expression of the mutant huntingtin protein that is produced in HD patients. (see ).
DMM calls for improved inclusion, analysis and reporting of sex as a biological variable in preclinical animal modelling research. Read the full Editorial by Monica J. Justice.
DMM’s new series - Building advocacy into research - features interviews, ‘The Patient’s Voice’, with patients and advocates for a range of disease types, with the aim of supporting the highest quality research for the benefit of all patients affected by disease.
DMM and its sister journals offer Travelling Fellowships of up to £3,000 to graduate students and post-doctoral researchers wishing to make collaborative visits to other laboratories. Find out more about our Travelling Fellowships and read stories from previous grant recipients.
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
