Simultaneous exposure to multiple allergens can enhance the allergic response through airway hyperresponsiveness (AHR). Research presented here by Franco DiGiovanni and colleagues combines mouse models of allergen challenge to simulate dual allergen exposure. Mice that are chronically and simultaneously exposed to ovalbumin and dust mite allergens have sustained AHR when compared with animals chronically treated with each allergen alone, highlighting the important combinatorial effect of allergens on the inflammatory response.

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