Loss of epithelial polarity redirects Notch signaling and triggers a Xrp1 response during neoplastic growth in Drosophilaby Logeay et al.

Invasive Procedure: new insights into how changes in epithelial structure can turn Notch nasty.

Selected by Sally Lowell. Read the guest preLight here

The WD and linker domains of ATG16L1 required for non-canonical autophagy limit lethal influenza A virus infection at epithelial surfacesby Wang et al.

Loss of non-canonical autophagy in mice increases sensitivity to influenza A virus infection by disrupting defences at the lung epithelial barrier, but not in phagocytic leukocytes.

Selected by Kirsty Hooper. Read the preLight here

Bariatric surgery reveals a gut-restricted TGR5 agonist that exhibits anti-diabetic effectsby Chaudhari et al.

A gut check for bariatric surgery – Surgery-mediated bile acid changes improve metabolic parameters.

Selected by Connor Rosen. Read the preLight here

NINJA: an inducible genetic model for creating neoantigens in vivoby Damo et al.

A neoantigen in disguise, the NINJA system: testing the functionality of a novel genetically engineered mouse model with an inducible neoantigen construct.

Selected by Deborah Caswell. Read the preLight here

Obesity-driven changes in ECM composition promote local invasion and metastasis of breast tumorsby Wishart et al.

Obesity and breast cancer – Collagen VI in the spotlight

Selected by Vassilis Papalazarou and Anh Hoang Le. Read the preLight here

Regeneration in the adult Drosophila brainby Crocker et al.

A hidden stem cell-like population found in the Drosophila brain: let's regenerate.

Selected by Ivana Viktorinová. Read the preLight here

On-demand spatiotemporal programming of collective cell migration via bioelectric stimulationby Zajdel et al.

An electricity-based pied piper of Hamelin: moving cells on demand.

Selected by Mariana De Niz. Read the preLight here

Mutational signatures are jointly shaped by DNA damage and repairby Volkova et al.

A combinatory mutational screen in C. elegans, combining 54 DNA repair mutants and 12 genotoxins, demonstrates that mutations are a result of both DNA damage and failed repair.

Selected by Kerryn Elliott. Read the preLight here

Chemogenetic analysis of how receptors for short chain fatty acids regulate the gut-brain axisby Barki et al.

Following your gut – using chemogenetics to understand how short chain fatty acids regulate the gut-brain axis.

Selected by Phyllis Phuah. Read the preLight here