Disease Models & Mechanisms (DMM) is an Open Access biomedical research journal focusing on the use of model systems to better understand, diagnose and treat human disease.
The primary aim of DMM is to promote human health by inspiring collaboration between basic and clinical researchers in translational science. The journal is committed to presenting rigorously peer-reviewed research that has significant translational impact. The interdisciplinary nature of DMM means that a diverse range of diseases, approaches and models fall within its broad scope. DMM is guided by an international team of expert research-active Editors, led by Editor-in-Chief Elizabeth Patton and Deputy Editor-in-Chief Elaine Mardis, and supported by an outstanding Editorial Advisory Board.
DMM marks 100 years of insulin
It has been 100 years since the discovery of insulin. This then revolutionary treatment now saves the lives of millions of people living with diabetes, but much remains to be understood of its mechanisms and roles in homeostasis and disease.
November is Diabetes Awareness Month. DMM marks this and the centenary of the discovery of insulin with specially commissioned articles. More articles can be found in our Metabolic Disorders collection.
EDITORIAL: What lies beyond 100 years of insulin.
A MODEL FOR LIFE: Celebrating 100 years of insulin with Dr Elizabeth Seaquist.
PERSPECTIVE: Advances in diet-induced rodent models of metabolically acquired peripheral neuropathy by Stéphanie A. Eid and Eva L. Feldman
DMM Special Issue
Guest Editors: Donita Brady and Arvin Dar
Recent work has highlighted the roles of RAS dysregulation in cancer, aging and developmental disorders. Our new special issue, The RAS Pathway: Diseases, Therapeutics and Beyond, is now open.
Reviews from DMM
Ottersbach and colleagues discuss how MLL gene rearrangements cooperate with transient facilitators presented by the foetal environment to initiate the development of infant leukaemia, and evaluate current leukaemia models.
Clapcote et al. provide an overview of the animal models used to study the spectrum of ATP1A3-related disorders. They also discuss their contribution towards better understanding of pathological mechanisms and novel therapeutics.
Comprehensive phenotyping by the Tybulewicz group shows that Dp1Tyb mice, a model of Down syndrome (DS), have a broad range of DS-related phenotypes, and can be used to investigate causative genes and their pathological mechanisms.
This year’s Nobel Prize in Physiology or Medicine celebrates how even the most fundamental of science can lead to broad applications for improving health and wellbeing. Darren Logan describes the story behind research into the receptor channels responsible for the perception of touch and temperature.