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Disease Models & Mechanisms (DMM) is an Open Access biomedical research journal advancing novel insight into the mechanism, diagnosis and therapy of human disease.

DMM is committed to publishing rigorously peer-reviewed research in disease biology that has significant translational impact at the interface of basic and clinical science. Our content is freely available to our communities of basic and clinical researchers, health professionals, patients and their advocates and families. DMM is interdisciplinary in scope, and covers a diverse range of diseases. We also publish cutting-edge techniques and resources that advance the disease biology field.

DMM is led by an international team of expert research-active Editors, including Editor-in-Chief Liz Patton and Deputy Editor-in-Chief Elaine Mardis, and supported by an outstanding Editorial Advisory Board.

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DMM included in Read & Publish agreements

DMM is included in many of the Read & Publish agreements offered by The Company of Biologists. This enables discounted or fee-free publication of an uncapped number of Research or Resource articles in DMM for corresponding authors at more than 600 participating institutions from 41 countries worldwide.

The Forest of Biologists The Forest of Biologists leaves icon

As part of a new biodiversity initiative from The Company of Biologists, DMM now plants a native tree in a UK forest for each published Research and Review article. We are also funding the restoration and preservation of ancient woodland and dedicating these trees to our peer reviewers. All of these trees are represented together in a virtual forest. Read the Editorial to find out more about the launch of this initiative.

2023 DMM Journal Meeting - Registration now open!

Infectious Diseases Through an Evolutionary Lens

Special article

Registration is now open for the 2023 DMM Journal Meeting 'Infectious Diseases Through an Evolutionary Lens', organised by Wendy Barclay, Sara Cherry, David Tobin and Russell Vance. View our fantastic line up of speakers and register here.






DMM Outstanding Paper Prize 2022 winners

DMM is delighted to announce that the winners of the DMM Outstanding Paper Prize 2022 are Tamihiro Kamata for their Research Article on the pro- and anti-tumourigenic functions of statins, and Jennifer Sargent and Mark Warner from the Jackson Lab for their Resource Article on mouse models that allow grafting of human cancers.


Maximizing biomedical research impacts through bioethical considerations

Integrating bioethical frameworks and methodologies with biomedical research can have a key positive influence on the research's societal outcomes. In this Perspective, Valerie Tornini and colleagues provide a few non-exhaustive snapshots of bioethics in biomedical research contexts.


Intestinal barrier dysfunction: an evolutionarily conserved hallmark of aging

Anna Salazar and colleagues examine the importance of intestinal barrier function to organismal health and the mechanisms driving age-onset health decline.

Evolution and immunopathology of chikungunya virus informs therapeutic development

Filipa Henderson Sousa and colleagues provide an overview of chikungunya virus pathogenesis and explore recent advances in strategies to prevent and treat infections.

Editor's choice

PRDM1 DNA-binding zinc finger domain is required for normal limb development and is disrupted in split hand/foot malformation by Brittany T. Truong, Lomeli C. Shull, Ezra Lencer, Eric G. Bend, Michael Field, Elizabeth E. Blue, Michael J. Bamshad, Cindy Skinner, David Everman, Charles E. Schwartz, Heather Flanagan-Steet and Kristin B. Artinger

In this month’s Editor's choice Research Article, Kristin Artinger and colleagues identify novel variants of the transcription factor PRDM1 that lead to limb defects in humans and zebrafish.

In addition, Matthew Harris highlights the use of the zebrafish fin in this study to analyse the genetic networks underlying limb development.

Research Articles

Popovic and Yu et al. reveal the involvement of the Tribbles pseudokinases in the control of body weight, lifespan and sleep. 

Using mice models of Down syndrome, Sloan et al. show that triplicated Dyrk1a plays a sex-specific role in some skeletal phenotypes, and Moyer et al. identify human chromosome 21 genes that might modulate Sonic hedgehog signalling in Down syndrome.

Journals from The Company of Biologists

Development current cover
Journal of Cell Science current cover
Journal of Experimental Biology current cover
Disease Models and Mechanisms current cover
Biology Open current cover
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