... system defective ( vnd ), intermediate neuroblasts defective ( ind ) and muscle segment homeobox ( msh ) subdivides the truncal neuroectoderm(primordium of the ventral nerve cord) into a ventral, intermediate and dorsal longitudinal domain, and has been shown to play a key role in the formation...

... of Nkx6 in all postmitotic neurons severely reduces Eve expression in the U MNs and EL neurons, though Eve expression in RP2 and aCC/pCC appears grossly normal (compare Fig. 3D,E ). However, as observed for vnd , Eve expression is normal in Nkx6 mutant embryos (data not shown). Thus, Nkx6...

... for a role for vertebrate Sox genes in neural differentiation, its mode of action remains unclear as neither target genes nor CNS interaction partners have been identified. Our observations that SoxN genetically interacts with vnd and ind suggest the vertebrate homologs of Vnd [Nkx2.2 family ( Pabst et...

... of a component of this pathway leads to a phenotype identical to that in DER mutants. MAP-kinase activation was also observed in the medial column where esg and proneural gene expression is unaffected by DER. We found that the homeobox gene vnd is required for the expression of esg and scute in the medial column...